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Storage and executive processes in the frontal lobes.
- Science,
, 1999
"... The human frontal cortex helps mediate working memory, a system that is used for temporary storage and manipulation of information and that is involved in many higher cognitive functions. Working memory includes two components: short-term storage (on the order of seconds) and executive processes th ..."
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Cited by 401 (5 self)
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The human frontal cortex helps mediate working memory, a system that is used for temporary storage and manipulation of information and that is involved in many higher cognitive functions. Working memory includes two components: short-term storage (on the order of seconds) and executive processes that operate on the contents of storage. Recently, these two components have been investigated in functional neuroimaging studies. Studies of storage indicate that different frontal regions are activated for different kinds of information: storage for verbal materials activates Broca's area and left-hemisphere supplementary and premotor areas; storage of spatial information activates the right-hemisphere premotor cortex; and storage of object information activates other areas of the prefrontal cortex. Two of the fundamental executive processes are selective attention and task management. Both processes activate the anterior cingulate and dorsolateral prefrontal cortex. T he frontal cortex comprises a third of the human brain; it is the structure that enables us to engage in higher cognitive functions such as planning and problem solving (1). What are the processes that serve as the building blocks of these higher cognitive functions, and how are these implemented in frontal cortex? Recent discussions of this issue have focused on working memory, a system used for temporary storage and manipulation of information. The system is divided into two general components: short-term storage and a set of "executive processes." Short-term storage involves active maintenance of a limited amount of information for a matter of seconds; it is a necessary component of many higher cognitive functions (2) and is mediated in part by the prefrontal cortex (PFC) (3). Executive processes are implemented by PFC as well (4). Although executive processes often operate on the contents of short-term storage, the two components of working memory can be dissociated: there are neurological patients who have intact short-term storage but defective executive processes and vice versa (5). We review here neuroimaging studies of these two components of working memory. We consider experiments that have used positron emission tomography (PET) or functional magnetic resonance imaging (fMRI) to image participants while they engage in cognitive tasks that are designed to reveal processes of interest, such as tasks that isolate short-term storage of verbal material. We concentrate on studies in which participants performed an experimental and a control task while being scanned and in which the control task has typically been chosen so that it differs from the experimental task only in a process of interest; a comparison of the experimental and control tasks thus reveals activations due to the process of interest (6). These paradigms contrast with standard neuropsychological tasks that may have diagnostic value for patients with frontal cortical lesions but that do not reveal individual cognitive processes. Storage Processes and the Frontal Lobes Many neuroimaging studies are founded on Baddeley's (7) model of working memory. In part, it posits separate storage buffers for verbal and visual-spatial information. Baddeley further argued that verbal storage can be decomposed into a phonological buffer for short-term maintenance of phonological information and a subvocal rehearsal process that refreshes the contents of the buffer. We examine evidence about each aspect of this model as it relates to frontal cortex. Verbal storage. Some evidence about storage mechanisms comes from experiments with the item-recognition task (8)
Deictic Codes for the Embodiment of Cognition
- Behavioral and Brain Sciences
, 1995
"... To describe phenomena that occur at different time scales, computational models of the brain must necessarily incorporate different levels of abstraction. We argue that at time scales of approximately one-third of a second, orienting movements of the body play a crucial role in cognition and form a ..."
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Cited by 321 (19 self)
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To describe phenomena that occur at different time scales, computational models of the brain must necessarily incorporate different levels of abstraction. We argue that at time scales of approximately one-third of a second, orienting movements of the body play a crucial role in cognition and form a useful computational level, termed the embodiment level . At this level, the constraints of the body determine the nature of cognitive operations, since the natural sequentiality of body movements can be matched to the natural computational economies of sequential decision systems. The way this is done is through a system of implicit reference termed deictic, whereby pointing movements are used to bind objects in the world to cognitive programs. We show how deictic bindings enable the solution of natural tasks and argue that one of the central features of cognition, working memory, can be related to moment-by-moment dispositions of body features such as eye movements and hand movements. Keyw...
Empathy: Its ultimate and proximate bases
- Behavioral and Brain Sciences
, 2002
"... The empathy literature is characterized by debate regarding the nature of the phenomenon. We propose a unified theory of empathy, divided into ultimate and proximate levels, grounded in the emotional link between individuals. On an ultimate level, emotional linkage supports group alarm, vicariousnes ..."
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Cited by 234 (5 self)
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The empathy literature is characterized by debate regarding the nature of the phenomenon. We propose a unified theory of empathy, divided into ultimate and proximate levels, grounded in the emotional link between individuals. On an ultimate level, emotional linkage supports group alarm, vicariousness of emotions, mother-infant responsiveness, and the modeling of competitors and predators; these exist across species and greatly effect reproductive success. Proximately, emotional linkage arises from a direct mapping of another's behavioral state onto a subject's behavioral representations, which activate responses in the subject. This ultimate and proximate account parsimoniously explains different phylogenetic and ontogenetic levels of empathy. The empathy literature has been characterized by disagreement regarding the exact nature of the phenomenon. There are emotional, cognitive, and conditioning views of empathy, and these views apply to different extents across species. We argue that with an adequate description of the ultimate and proximate mechanism, these views can be cohered into a unified whole. We use an interdisciplinary approach along ultimate and proximate levels for a unified theory grounded in the fact that individuals are behaviorally, physiologically and neurologically linked. These forms of
The Somatic Marker Hypothesis: A Neural Theory of Economic Decision’,
- Games and Economic Behavior,
, 2005
"... Abstract Modern economic theory ignores the influence of emotions on decision-making. Emerging neuroscience evidence suggests that sound and rational decision making, in fact, depends on prior accurate emotional processing. The somatic marker hypothesis provides a systems-level neuroanatomical and ..."
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Cited by 203 (11 self)
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Abstract Modern economic theory ignores the influence of emotions on decision-making. Emerging neuroscience evidence suggests that sound and rational decision making, in fact, depends on prior accurate emotional processing. The somatic marker hypothesis provides a systems-level neuroanatomical and cognitive framework for decision-making and its influence by emotion. The key idea of this hypothesis is that decision-making is a process that is influenced by marker signals that arise in bioregulatory processes, including those that express themselves in emotions and feelings. This influence can occur at multiple levels of operation, some of which occur consciously, and some of which occur non-consciously. Here we review studies that confirm various predictions from the hypothesis, and propose a neural model for economic decision, in which emotions are a major factor in the interaction between environmental conditions and human decision processes, with these emotional systems providing valuable implicit or explicit knowledge for making fast and advantageous decisions.
The role of prefrontal cortex in working-memory capacity, executive attention, and general fluid intelligence: An individual-differences perspective
, 2002
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A cortical mechanism for triggering top-down facilitation in visual object recognition
- J Cogn
"... & The majority of the research related to visual recognition has so far focused on bottom-up analysis, where the input is processed in a cascade of cortical regions that analyze increasingly complex information. Gradually more studies emphasize the role of top-down facilitation in cortical analy ..."
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Cited by 169 (14 self)
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& The majority of the research related to visual recognition has so far focused on bottom-up analysis, where the input is processed in a cascade of cortical regions that analyze increasingly complex information. Gradually more studies emphasize the role of top-down facilitation in cortical analysis, but it remains something of a mystery how such processing would be initiated. After all, top-down facilitation implies that high-level information is activated earlier than some relevant lower-level information. Building on previous studies, I propose a specific mechanism for the activation of top-down facilitation during visual object recognition. The gist of this hypothesis is that a partially analyzed version of the input image (i.e., a blurred image) is projected rapidly from early visual areas directly to the prefrontal cortex (PFC). This coarse representation activates in the PFC expectations about the most likely interpretations of the input image, which are then back-projected as an ‘‘initial guess’ ’ to the temporal cortex to be integrated with the bottom-up analysis. The top-down process facilitates recognition by substantially limiting the number of object representations that need to be considered. Furthermore, such a rapid mechanism may provide critical information when a quick response is necessary. &
Interactions Between Frontal Cortex and Basal Ganglia in Working Memory: A Computational Model
, 2000
"... The frontal cortex and basal ganglia interact via a relatively well-understood and elaborate system of interconnections. In the context of motor function, these interconnections can be understood as disinhibiting or "releasing the brakes" on frontal motor action plans --- the basal ganglia ..."
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Cited by 152 (18 self)
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The frontal cortex and basal ganglia interact via a relatively well-understood and elaborate system of interconnections. In the context of motor function, these interconnections can be understood as disinhibiting or "releasing the brakes" on frontal motor action plans --- the basal ganglia detect appropriate contexts for performing motor actions, and enable the frontal cortex to execute such actions at the appropriate time. We build on this idea in the domain of working memory through the use of computational neural network models of this circuit. In our model, the frontal cortex exhibits robust active maintenance, while the basal ganglia contribute a selective, dynamic gating function that enables frontal memory representations to be rapidly updated in a task-relevant manner. We apply the model to a novel version of the continuous performance task (CPT) that requires subroutine-like selective working memory updating, and compare and contrast our model with other existing models and th...
A symbolic-connectionist theory of relational inference and generalization
- Psychological Review
, 2003
"... The authors present a theory of how relational inference and generalization can be accomplished within a cognitive architecture that is psychologically and neurally realistic. Their proposal is a form of symbolic connectionism: a connectionist system based on distributed representations of concept m ..."
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Cited by 134 (26 self)
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The authors present a theory of how relational inference and generalization can be accomplished within a cognitive architecture that is psychologically and neurally realistic. Their proposal is a form of symbolic connectionism: a connectionist system based on distributed representations of concept meanings, using temporal synchrony to bind fillers and roles into relational structures. The authors present a specific instantiation of their theory in the form of a computer simulation model, Learning and Inference with Schemas and Analogies (LISA). By using a kind of self-supervised learning, LISA can make specific inferences and form new relational generalizations and can hence acquire new schemas by induction from examples. The authors demonstrate the sufficiency of the model by using it to simulate a body of empirical phenomena concerning analogical inference and relational generalization. A fundamental aspect of human intelligence is the ability to form and manipulate relational representations. Examples of relational thinking include the ability to appreciate analogies between seemingly different objects or events (Gentner, 1983; Holyoak & Thagard, 1995), the ability to apply abstract rules in novel situations (e.g., Smith, Langston, & Nisbett, 1992), the ability to understand and learn language (e.g., Kim, Pinker, Prince, & Prasada, 1991), and even the ability to appreciate perceptual similarities
Mapping motor inhibition: Conjunctive brain activations across different versions of go/no-go and stop tasks. NeuroImage 13: 250–261
, 2001
"... Conjunction analysis methods were used in functional magnetic resonance imaging to investigate brain regions commonly activated in subjects performing different versions of go/no-go and stop tasks, differing in probability of inhibitory signals and/or contrast conditions. Generic brain activation ma ..."
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Cited by 120 (0 self)
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Conjunction analysis methods were used in functional magnetic resonance imaging to investigate brain regions commonly activated in subjects performing different versions of go/no-go and stop tasks, differing in probability of inhibitory signals and/or contrast conditions. Generic brain activation maps highlighted brain regions commonly activated in (a) two different go/no-go task versions, (b) three different stop task versions, and (c) all 5 inhibition task versions. Comparison between the generic activation maps of stop and go/no-go task versions revealed inhibitory mechanisms specific to go/no-go or stop task performance in 15 healthy, right-handed, male adults. In the go/no-go task a motor response had to be selectively executed or inhibited in either 50 % or 30 % of
Muftuler T. Auditory-motor interaction revealed by fMRI: speech, music, and working memory in area Spt
- J Cogn Neurosci
"... & The concept of auditory – motor interaction pervades speech science research, yet the cortical systems supporting this interface have not been elucidated. Drawing on exper-imental designs used in recent work in sensory – motor integration in the cortical visual system, we used fMRI in an effor ..."
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Cited by 93 (7 self)
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& The concept of auditory – motor interaction pervades speech science research, yet the cortical systems supporting this interface have not been elucidated. Drawing on exper-imental designs used in recent work in sensory – motor integration in the cortical visual system, we used fMRI in an effort to identify human auditory regions with both sensory and motor response properties, analogous to single-unit responses in known visuomotor integration areas. The sensory phase of the task involved listening to speech (nonsense sentences) or music (novel piano melodies); the ‘‘motor’ ’ phase of the task involved covert rehearsal/humming of the auditory stimuli. A small set of areas in the superior temporal and temporal– parietal cortex responded both during the listening phase and the rehearsal/humming phase. A left lateralized region in the posterior Sylvian fissure at the parietal – temporal boundary, area Spt, showed particularly robust responses to both phases of the task. Frontal areas also showed combined auditory + rehearsal responsivity consistent with the claim that the posterior activations are part of a larger auditory–motor integration circuit. We hypothesize that this circuit plays an important role in speech development as part of the network that enables acoustic–phonetic input to guide the acquisition of language-specific articulatory-phonetic gestures; this circuit may play a role in analogous musical abilities. In the adult, this system continues to support aspects of speech production, and, we suggest, supports verbal working memory. &