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103
Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis. Crit Care Med.
, 2006
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J: Correlation of procalcitonin and C-reactive protein to inflammation, complications, and outcome during the intensive care unit course of multipletrauma patients. Crit Care
, 2006
"... inflammation, complications, and outcome during the intensive care unit course of multiple-trauma patients ..."
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inflammation, complications, and outcome during the intensive care unit course of multiple-trauma patients
Detection and characterization of 3D-signature phosphorylation
, 2009
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Usefulness of five-item and three-item Mental Health Inventories to screen for depressive symptoms in the general population of Japan
, 2005
"... This is an Open Access article distributed under the terms of the Creative Commons Attribution License ..."
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License
The fourdimensional symptom questionnaire (4DSQ): measuring distress and other mental health problems in a working population. Work Stress
"... In non-clinical (working) populations it is important to differentiate between general distress, on the one hand, and psychiatric symptoms*/depression, anxiety and somatization*/on the other hand. The Four-Dimensional Symptom Questionnaire (4DSQ) is a new instrument that measures these four symptom ..."
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In non-clinical (working) populations it is important to differentiate between general distress, on the one hand, and psychiatric symptoms*/depression, anxiety and somatization*/on the other hand. The Four-Dimensional Symptom Questionnaire (4DSQ) is a new instrument that measures these four symptom dimensions (Terluin, 1996). This study aimed to investigate the psychometric properties of the 4DSQ in a working population. A postal stress and health survey was sent to all employees of a Dutch telecom company, 51 % of whom responded (N/3852). The mailing included the 4DSQ, a set of questionnaires concerning job stress (e.g. psychological demands), coping style (e.g. problem-focused coping, avoidant coping), and indicators of strain (e.g. emotional exhaustion, fatigue). Cronbach’s a for the four sub-scales of the 4DSQ ranged from.79 to.90. Factor analysis showed four factors corresponding to the four scales of the 4DSQ: distress, depression, anxiety, and somatization. The validity of the 4DSQ was assessed using (partial) correlations with job stress, coping, and strain. As expected, the distress scale showed the strongest correlations with the indicators of strain, as well as with job stress and coping. In conclusion, the 4DSQ is a reliable and valid instrument that can be used in a working population to distinguish between stress-related symptoms and psychiatric illness.
Analysis of creatine kinase, CK-MB, myoglobin, and troponin T time-activity curves for early assessment of coronary artery reperfusion after intravenous throm- bolysis. Circulation
"... Background. Thrombolysis has become the standard therapeutic approach in patients with acute myocardial infarction. To identify patients who may benefit from early invasive procedures, reliable noninvasive assessment of success or failure of thrombolytic therapy is mandatory. Methods and Results. In ..."
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Background. Thrombolysis has become the standard therapeutic approach in patients with acute myocardial infarction. To identify patients who may benefit from early invasive procedures, reliable noninvasive assessment of success or failure of thrombolytic therapy is mandatory. Methods and Results. In a prospective study in 63 consecutive patients undergoing thrombolysis for their first myocardial infarction, serial measurements of creatine kinase (CK), its isoenzyme CK-MB, myoglobin, and troponin T were done to determine their value for noninvasive prediction of coronary artery patency. Blood samples were drawn every 15 minutes during the first 90 minutes, every 30 minutes during the first 4 hours, every 4 hours during the first 24 hours, and every 8 hours during the first 72 hours. The perfusion status of the infarct-related artery was assessed angiographically 90 minutes after initiation of thrombolysis. For each marker, time to its peak concentration and its early initial slope (start of thrombolysis to 90 minutes thereafter) were determined. Areas under receiver operator characteristic (ROC) curves were 0.83, 0.76, 0.82, and 0.80 for maxima of CK, CK-MB, myoglobin, and troponin T, respectively (p=NS by univariate Z test). The corresponding values for early slopes of CK, CK-MB, myoglobin, and troponin T were 0.79, 0.82, 0.89, and 0.80 (p =0.23 for comparison between myoglobin and CK-MB;p=0.07 between myoglobin and CK). Sensitivity, specificity, and positive and negative predictive
Diagnostic accuracy of pattern differentiation algorithm based on
, 2009
"... Chinese medicine theory: a stochastic simulation study ..."
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Chinese medicine theory: a stochastic simulation study
NT-proBNP for Pulmonologists: Not Only a Rule-Out Test for Systolic Heart Failure but Also a Global Marker of Heart Disease
"... Using predefined cut-off values of 93 pg/ml (men) and 144 pg/ml (women), sensitivity was 0.75 and specificity was 0.79 for identifying heart disease. The negative predictive value was 0.90. If heart disease had to be considered as a cause of the dyspnea, sensitivity and the negative predictive value ..."
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Using predefined cut-off values of 93 pg/ml (men) and 144 pg/ml (women), sensitivity was 0.75 and specificity was 0.79 for identifying heart disease. The negative predictive value was 0.90. If heart disease had to be considered as a cause of the dyspnea, sensitivity and the negative predictive value went up to 0.90 and 0.97, respectively. Conclusions: NT-proBNP performs well as a test for ruling out cardiac dys-pnea. It is also useful as a rule-in test for heart disease, which enables the pulmonologist to appropriately select candi-dates for in-depth evaluation by cardiology. Copyright © 2009 S. Karger AG, Basel
Statistical Evaluation of a Biomarker
, 2010
"... ABSTRACT A biomarker may provide a diagnosis, assess disease severity or risk, or guide other clinical interventions such as the use of drugs. Although considerable progress has been made in standardizing the methodology and reporting of randomized trials, less has been accomplished concerning the ..."
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ABSTRACT A biomarker may provide a diagnosis, assess disease severity or risk, or guide other clinical interventions such as the use of drugs. Although considerable progress has been made in standardizing the methodology and reporting of randomized trials, less has been accomplished concerning the assessment of biomarkers. Biomarker studies are often presented with poor biostatistics and methodologic flaws that precludes them from providing a reliable and reproducible scientific message. A host of issues are discussed that can improve the statistical evaluation and reporting of biomarker studies. Investigators should be aware of these issues when designing their studies, editors and reviewers when analyzing a manuscript, and readers when interpreting results. H ISTORICALLY, the term biomarker referred to analytes in biologic samples that predict a patient's disease state. However, the term biomarker has evolved over time to any biologic measurement, recently including genomic or proteomic analyses, that could also predict a response to a drug (efficacy, toxicity, or pharmacokinetics) or indicate an underlying physiologic mechanism. 1 New biomarkers exploring the cardiovascular system, kidney, central nervous system, inflammation, and sepsis are under the scrutiny of bioengineering companies, and we are witnessing a biomarkers revolution similar to the imaging technique revolution. Remarkably, this revolution has already occurred for cancer drugs. 1 Assessment of these biomarkers is complex but valuable in perioperative and critical care medicine as markers of diagnosis, disease severity, and risk. Although considerable progress has been made in standardizing the methodology and reporting of randomized trials, less has been accomplished concerning the assessment of diagnostic and prognostic biomarkers. Analysis of the literature, even in prestigious journals, has revealed that the methodologic quality of diagnostic studies is on average poor. 3 Recommendations concerning the reporting of diagnostic studies, the Standards for Reporting of Diagnostic Accuracy (STARD) initiative, have been published recently, 4 several years after the first recommendations concerning reporting of randomized trials. 5 However, these recommendations do not encompass all issues of this rapidly evolving domain. The purpose of this article was to provide the anesthesiologist with a comprehensive introduction of the problems, potential solutions, and limitations raised by the assessment of the diagnostic properties of modern biomarkers. It is important to appreciate the available statistical methodologic tools to face the biomarker revolution, either as a clinical investigator or as a consumer of scientific literature. This is no easy task, for we must now look beyond the classic diagnostic indices (sensitivity, specificity, and predictive values) and even beyond the more widely used receiver operating characteristic (ROC) curves by integrating the principles of Bayesian theory. To appreciate these issues, the different roles of a biomarker must first be explored. Role of a Biomarker A biomarker may serve different roles
Open Access
, 2006
"... Identification of novel regulatory modules in dicotyledonous plants using expression data and comparative genomics ..."
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Identification of novel regulatory modules in dicotyledonous plants using expression data and comparative genomics
