Amazon’s Mechanical Turk provides a programmatically accessible micro-task market, allowing a program to hire human workers. This has opened the door to a rich field of research in human computation where programs orchestrate the efforts of humans to help solve problems. This thesis explores challenges that programmers face in this space: both technical challenges like managing high-latency, as well as psychological challenges like designing effective interfaces for human workers. We offer tools and experiments to overcome these challenges in an effort to help future researchers better understand and harness the power of human computation. The main tool this thesis offers is the crash-and-rerun programming model for managing high-latency tasks on MTurk, along with the TurKit toolkit which implements crash-and-rerun. TurKit provides a straightforward imperative programming environment where MTurk is abstracted as a function call. Based on our experience using TurKit, we propose a simple model of human computation algorithms involving creation and decision tasks. These tasks suggest two natural workflows: iterative