The head-direction (HD) cells found in the limbic system in freely moving rats represent the instantaneous head direction of the animal in the horizontal plane regardless of the location of the animal. The internal direction represented by these cells uses both self-motion information for inet-tially based updating and familiar visual landmarks for calibration. Here, a model of the dynamics of the HD cell ensemble is presented. The sta-bility of a localized static activity profile in the network and a dynamic shift mechanism are explained naturally by synaptic weight distribution components with even and odd symmetry, respectively. Under symmetric weights or symmetric reciprocal connections, a stable activity profile close to the known direc-tional tuning curves will emerge. By adding a slight asymmetry to the weights, the activity profile will shift continuously without 1

Hippocampal ‘place ’ cells and the head-direction cells of the dorsal presubiculum and related neocortical and thalamic areas appear to be part of a preconfigured network that generates an abstract internal representation of two-dimensional space whose metric is self-motion. It appears that viewpoint-specific visual information (e.g. landmarks) becomes secondarily bound to this structure by associative learning. These associations between landmarks and the preconfigured path integrator serve to set the origin for path integration and to correct for cumulative

Introduction Neuronal activity due to recurrent excitations in the form of a spatially localized pulse or bump has been proposed as a mechanism for feature selectivity in models of the visual system (Somers, Nelson, & Sur, 1995; Hansel & Sompolinsky, 1998), the head direction system (Skaggs, Knieram, Kudrimoti, & McNaughton, 1995; Zhang, 1996; Redish, Elga, & Touretzky, 1996), and working memory (Wilson & Cowan, 1973; Amit & Brunel, 1997; Camperi & Wang, 1998). Many of the previous mathematical formulations of such structures have employedpopulation rate models (Wilson &Cowan, 1972, 1973; Amari, 1977; Kishimoto & Amari, 1979; Hansel & Sompolinsky, 1998). (See Ermentrout, 1998, for a recent review.) Here, we consider a network of spiking neurons that shows such structures and investigate their properties. In our network we #nd localized time-stationary states

The medial temporal lobe (MTL) has been studied extensively at all levels of analysis, yet its function remains unclear. Theory regarding the cognitive function of the MTL has centered along 3 themes. Different authors have emphasized the role of the MTL in episodic recall, spatial navigation, or relational memory. Starting with the temporal context model (M.W. Howard and M. J. Kahana, 2002), a distributed memory model that has been applied to benchmark data from episodic recall tasks, the authors propose that the entorhinal cortex supports a gradually changing representation of temporal context and the hippocampus proper enables retrieval of these contextual states. Simulation studies show this hypothesis explains the firing of place cells in the entorhinal cortex and the behavioral effects of hippocampal lesion in relational memory tasks. These results constitute a first step towards a unified computational theory of MTL function that integrates neurophysiological, neuropsychological and cognitive findings.

The authors model the neural mechanisms underlying spatial cognition, integrating neuronal systems and behavioral data, and address the relationships between long-term memory, short-term memory, and imagery, and between egocentric and allocentric and visual and ideothetic representations. Long-term spatial memory is modeled as attractor dynamics within medial–temporal allocentric representations, and short-term memory is modeled as egocentric parietal representations driven by perception, retrieval, and imagery and modulated by directed attention. Both encoding and retrieval/imagery require translation between egocentric and allocentric representations, which are mediated by posterior parietal and retrosplenial areas and the use of head direction representations in Papez’s circuit. Thus, the hippocampus effectively indexes information by real or imagined location, whereas Papez’s circuit translates to imagery or from perception according to the direction of view. Modulation of this translation by motor efference allows spatial updating of representations, whereas prefrontal simulated motor efference allows mental exploration. The alternating temporal–parietal flows of information are organized by the theta rhythm. Simulations demonstrate the retrieval and updating of familiar spatial scenes, hemispatial neglect in memory, and the effects on hippocampal place cell firing of lesioned head direction representations and of conflicting visual and ideothetic inputs.

We propose a computational model which is consistent with several neurophysiological findings concerning biological head-direction cells and hippocampal place cells. The model consists of two separate neural systems providing directional and place coding representations, respectively. These two modules are strongly coupled and interact with each other to form a unitary spatial learning system. We stress the importance of correlating idiothetic and allothetic signals to determine the dynamics of the system in order to stabilize head-direction and place representations over time. We give experimental results obtained by implementing the entire model on a real mobile robot. 1. Introduction Directional sense and place coding are crucial capabilities for solving spatial cognitive tasks. Neurophysiological findings suggest the existence of neural representations of direction and position as a basis for animal spatial behavior (O'Keefe & Nadel, 1978; Taube et al., 1990). Experi...

Geometric alterations to the boundaries of a virtual environment were used to investigate the representations underlying human spatial memory. Subjects encountered a cue object in a simple rectangular enclosure, with distant landmarks for orientation. After a brief delay, during which they were removed from the arena, subjects were returned to it at a new location and orientation and asked to mark the place where the cue had been. On some trials the geometry (size, aspect ratio) of the arena was varied between presentation and testing. Responses tended to lie somewhere between a location that maintained fixed distances from nearby walls and a location that maintained fixed ratios of the distances between opposing walls. The former were more common after expansions and for cued locations nearer to the edge while the latter were more common after contractions and for locations nearer to the center. The spatial distributions of responses predicted by various simple geometric models were compared to the data. The best fitting model was one derived from the response properties of `place cells' in the rat hippocampus, which matches the `proximities' c of the cue to the four walls of the arena, where d is the distance to a wall and c is a global constant. Subjects also tended to adopt the same orientation at presentation and testing, although this was not due to using a view matching strategy, which could be ruled out in 50% of responses. Disoriented responses were most often seen where the cued location was near the center of the arena or where the long axis of a rectangular arena was changed between presentation and testing, suggesting that the geometry of the arena acts as a weak cue to orientation. Overall, the results suggest a process of visual landmark matching to det...

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. Based on head direction experiments in rats, the existence of localized bumps of thalamic activity has been proposed. We computationally demonstrate the existence of a novel class of localized bump solutions in a two-layer conductancebased thalamic network and analyze the mechanisms behind these stable patterns. In contrast to previous models of bump activity, here inhibition plays a crucial role in initially spreading neuronal ring and in subsequently sustaining it. In our model, we incorporate local strong, fast GABAA inhibition and diuse weak, slow GABAB inhibition, based on previous biophysical experiments. These forms of inhibition contribute in dierent, yet complementary, ways to the observed pattern formation. Keywords: localized activity, head direction cells, thalamus, conductance-based model, synaptic coupling Abbreviations: GABA { -aminobutyric acid; HD { head direction; PoS { postsubiculum; ATN { anterior thalamic nuclei; AD { anterior dorsal thalamic nucleus; TC { t...

The place fields of hippocampal cells in old animals sometimes change when an animal is removed from and then returned to an environment [ Barnes et al., 1997 ] . The ensemble correlation between two sequential visits to the same environment shows a strong bimodality for old animals (near 0, indicative of remapping, and greater than 0.7, indicative of a similar representation between experiences), but a strong unimodality for young animals (greater than 0.7, indicative of a similar representation between experiences). One explanation for this is the multi-map hypothesis in which multiple maps are encoded in the hippocampus: old animals may sometimes be returning to the wrong map. A theory proposed by Samsonovich and McNaughton (1997) suggests that the Barnes et al. experiment implies that the maps are pre-wired in the CA3 region of hippocampus. Here, we offer an alternative explanation in which orthogonalization properties in the dentate gyrus (DG) region of hippocampus interact with e...