The i.-calculus is considered a useful mathematical tool in the study of programming languages, since programs can be identified with I-terms. However, if one goes further and uses bn-conversion to prove equivalence of programs, then a gross simplification is introduced (programs are identified with total functions from calues to values) that may jeopardise the applicability of theoretical results, In this paper we introduce calculi. based on a categorical semantics for computations, that provide a correct basis for proving equivalence of programs for a wide range of notions of computation.