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21
Online Bayes Point Machines
"... We present a new and simple algorithm for learning large margin classi ers that works in a truly online manner. The algorithm generates a linear classi er by averaging the weights associated with several perceptronlike algorithms run in parallel in order to approximate the Bayes point. A rand ..."
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Cited by 68 (3 self)
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We present a new and simple algorithm for learning large margin classi ers that works in a truly online manner. The algorithm generates a linear classi er by averaging the weights associated with several perceptronlike algorithms run in parallel in order to approximate the Bayes point. A random subsample of the incoming data stream is used to ensure diversity in the perceptron solutions. We experimentally study the algorithm's performance on online and batch learning settings.
Supervised Neural Gas with General Similarity Measure
 Neural Processing Letters
, 2003
"... Prototype based classi cation oers intuitive and sparse models with excellent generalization ability. However, these models usually crucially depend on the underlying Euclidian metric; moreover, online variants likely suer from the problem of local optima. We here propose a generalization of learni ..."
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Cited by 28 (20 self)
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Prototype based classi cation oers intuitive and sparse models with excellent generalization ability. However, these models usually crucially depend on the underlying Euclidian metric; moreover, online variants likely suer from the problem of local optima. We here propose a generalization of learning vector quantization with three additional features: (I) it directly integrates neighborhood cooperation, hence is less aected by local optima; (II) the method can be combined with any dierentiable similarity measure whereby metric parameters such as relevance factors of the input dimensions can automatically be adapted according to the given data; (III) it obeys a gradient dynamics hence shows very robust behavior, and the chosen objective is related to margin optimization.
Prototype Based Recognition of Splice Sites
 Bioinformatics using Computational Intelligence Paradigms
"... Introduction Rapid advances in biotechnology have made massive amounts of biological data available so that automated analyzing tools constitute a prerequisite to cope with huge and complex biological sequence data. Machine learning tools are used for widespread applications ranging from the iden ..."
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Cited by 7 (5 self)
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Introduction Rapid advances in biotechnology have made massive amounts of biological data available so that automated analyzing tools constitute a prerequisite to cope with huge and complex biological sequence data. Machine learning tools are used for widespread applications ranging from the identification of characteristic functional sites in genomic DNA [39], the prediction of protein secondary structure and higher structures [53], to the classification of the functionality of chemical compounds [5]. Here we will deal with a subproblem in de novo gene finding in DNA sequences of a given species, the problem of splice site recognition. For higher eukaryotic mechanisms gene finding requires the identification of the start and stop codons and the recognition of all introns, i.e. noncoding regions which are spliced out before transcription, that means all donor and acceptor sites of the sequence. The biological splicing process is only partially understood [64]. Fig. 1 depicts a sc
Neural Methods for NonStandard Data
 proceedings of the 12 th European Symposium on Artificial Neural Networks (ESANN 2004), dside pub
, 2004
"... Standard pattern recognition provides effective and noisetolerant tools for machine learning tasks; however, most approaches only deal with real vectors of a finite and fixed dimensionality. In this tutorial paper, we give an overview about extensions of pattern recognition towards nonstandard ..."
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Cited by 6 (3 self)
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Standard pattern recognition provides effective and noisetolerant tools for machine learning tasks; however, most approaches only deal with real vectors of a finite and fixed dimensionality. In this tutorial paper, we give an overview about extensions of pattern recognition towards nonstandard data which are not contained in a finite dimensional space, such as strings, sequences, trees, graphs, or functions. Two major directions can be distinguished in the neural networks literature: models can be based on a similarity measure adapted to nonstandard data, including kernel methods for structures as a very prominent approach, but also alternative metric based algorithms and functional networks; alternatively, nonstandard data can be processed recursively within supervised and unsupervised recurrent and recursive networks and fully recurrent systems.
Relevance LVQ versus SVM
 ARTIFICIAL INTELLIGENCE AND SOFTCOMPUTING, VOLUME 3070 OF SPRINGER LECTURE NOTES IN ARTIFICIAL INTELLIGENCE
, 2004
"... The support vector machine (SVM) constitutes one of the most successful current learning algorithms with excellent classification accuracy in large reallife problems and strong theoretical background. However, a SVM solution is given by a not intuitive classification in terms of extreme values o ..."
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Cited by 5 (3 self)
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The support vector machine (SVM) constitutes one of the most successful current learning algorithms with excellent classification accuracy in large reallife problems and strong theoretical background. However, a SVM solution is given by a not intuitive classification in terms of extreme values of the training set and the size of a SVM classifier scales with the number of training data. Generalized
Optimized cutting plane algorithm for largescale risk minimization
, 2009
"... We have developed an optimized cutting plane algorithm (OCA) for solving largescale risk minimization problems. We prove that the number of iterations OCA requires to converge to a ε precise solution is approximately linear in the sample size. We also derive OCAS, an OCAbased linear binary Support ..."
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Cited by 4 (1 self)
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We have developed an optimized cutting plane algorithm (OCA) for solving largescale risk minimization problems. We prove that the number of iterations OCA requires to converge to a ε precise solution is approximately linear in the sample size. We also derive OCAS, an OCAbased linear binary Support Vector Machine (SVM) solver, and OCAM, a linear multiclass SVM solver. In an extensive empirical evaluation we show that OCAS outperforms current stateoftheart SVM solvers like SVMlight, SVMperf and BMRM, achieving speedup factor more than 1,200 over SVMlight on some data sets and speedup factor of 29 over SVMperf, while obtaining the same precise support vector solution. OCAS, even in the early optimization steps, often shows faster convergence than the currently prevailing approximative methods in this domain, SGD and Pegasos. In addition, our proposed linear multiclass SVM solver, OCAM, achieves speedups of factor of up to 10 compared to SVMmulti−class. Finally, we use OCAS and OCAM in two realworld applications, the problem of human acceptor splice site detection and malware detection. Effectively parallelizing OCAS, we achieve stateoftheart results on an acceptor splice site recognition problem only by being able to learn from all the available 50 million examples in a 12milliondimensional feature space. Source code, data sets and scripts to reproduce the experiments are available at
Clustering with the Fisher Score
 ADVANCES IN NEURAL INFORMATION PROCESSING SYSTEMS 15
, 2003
"... Recently the Fisher score (or the Fisher kernel) is increasingly used as a feature extractor for classification problems. The Fisher score is a vector of parameter derivatives of loglikelihood of a probabilistic model. This paper gives a theoretical analysis about how class information is preserv ..."
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Cited by 4 (1 self)
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Recently the Fisher score (or the Fisher kernel) is increasingly used as a feature extractor for classification problems. The Fisher score is a vector of parameter derivatives of loglikelihood of a probabilistic model. This paper gives a theoretical analysis about how class information is preserved in the space of the Fisher score, which turns out that the Fisher score consists of a few important dimensions with class information and many nuisance dimensions. When we perform clustering with the Fisher score, KMeans type methods are obviously inappropriate because they make use of all dimensions. So we will develop a novel but simple clustering algorithm specialized for the Fisher score, which can exploit important dimensions. This algorithm is successfully tested in experiments with artificial data and real data (amino acid sequences).
Prototype based Machine Learning for Clinical Proteomics
, 2006
"... Clinical proteomics opens the way towards new insights into many diseases on a level of detail not available before. One of the most promising measurement techniques supporting this approach is mass spectrometry based clinical proteomics. The analysis of the high dimensional data obtained from mass ..."
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Cited by 3 (2 self)
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Clinical proteomics opens the way towards new insights into many diseases on a level of detail not available before. One of the most promising measurement techniques supporting this approach is mass spectrometry based clinical proteomics. The analysis of the high dimensional data obtained from mass spectrometry asks for sophisticated, problem adequate preprocessing and data analysis approaches. Ideally, automatic analysis tools provide insight into their behavior and the ability to extract further information, relevant for an understanding of the clinical data or applications such as biomarker discovery. Prototype based algorithms constitute efficient, intuitive and powerful machine learning methods which are very well suited to deal with high dimensional data and which allow good insight into their behavior by means of prototypical data locations. They have already successfully been applied to various problems in bioinformatics. The goal of this thesis is to extend prototype based methods, in such a way that they become suitable machine learning tools for typical problems in clinical proteomics. To achieve better adapted classification borders, tailored to the specific data distributions
Splice Site Detection with a HigherOrder Markov Model Implemented on a Neural Network
, 2003
"... The performance of the ab inito gene prediction approaches mostly depends on the e#ectiveness of detecting the splice sites. This paper addresses the problem of splice site detection using higherorder Markov models. The tenet of our approach is to brace the higherorder dependencies of a Markov ..."
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Cited by 3 (0 self)
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The performance of the ab inito gene prediction approaches mostly depends on the e#ectiveness of detecting the splice sites. This paper addresses the problem of splice site detection using higherorder Markov models. The tenet of our approach is to brace the higherorder dependencies of a Markov model by a neural network that receives the inputs from loworder Markov chains.
Cogenio (2001) Indagine circa la propensione delle PMI industriali a migrare verso sistemi operativi alternativi: il caso Linux
 Australian Computer Society, Inc
, 2004
"... Support Vector Machine is used to cluster data obtained from Amplified Fragment length Polymorphism screening of gastric cancer and normal tissue samples. Using the electrophoresis peak intensity measurements of the amplified fragments of the cancer and normal tissues, SVM was able to distinguish ga ..."
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Cited by 3 (0 self)
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Support Vector Machine is used to cluster data obtained from Amplified Fragment length Polymorphism screening of gastric cancer and normal tissue samples. Using the electrophoresis peak intensity measurements of the amplified fragments of the cancer and normal tissues, SVM was able to distinguish gastric cancer from normal tissue samples with a sensitivity of 0.98 and selectivity of 0.75. As AFLP is a low cost procedure which requires minimum prior sequence knowledge and biological material, SVM prediction of AFLP screening data is a potential tool for gastric cancer screening and diagnosis.