An articial immune system (ARTIS) is described which incorporates many properties of natural immune systems, including diversity, distributed computation, error tolerance, dynamic learning and adaptation and self-monitoring. ARTIS is a general framework for a distributed adaptive system and could, in principle, be applied to many domains. In this paper, ARTIS is applied to computer security, in the form of a network intrusion detection system called LISYS. LISYS is described and shown to be eective at detecting intrusions, while maintaining low false positive rates. Finally, similarities and dierences between ARTIS and Holland's classier systems are discussed. 1 INTRODUCTION The biological immune system (IS) is highly complicated and appears to be precisely tuned to the problem of detecting and eliminating infections. We believe that the IS provides a compelling example of a massively-parallel adaptive information-processing system, one which we can study for the purpose o...

This dissertation explores an immunological model of distributed detection, called negative detection, and studies its performance in the domain of intrusion detection on computer networks. The goal of the detection system is to distinguish between illegitimate behaviour (nonself ), and legitimate behaviour (self ). The detection system consists of sets of negative detectors that detect instances of nonself; these detectors are distributed across multiple locations. The negative detection model was developed previously; this research extends that previous work in several ways. Firstly, analyses are derived for the negative detection model. In particular, a framework for explicitly incorporating distribution is developed, and is used to demonstrate that negative detection is both scalable and robust. Furthermore, it is shown that any scalable distributed detection system that requires communication (memory sharing) is always less robust than a system that does not require communication...

We describe an artificial immune system (AIS) that is distributed, robust, dynamic, diverse and adaptive. It captures many features of the vertebrate immune system and places them in the context of the problem of protecting a network of computers from illegal intrusions.

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Bioreactor systems play an important role in tissue engineering, as they enable reproducible and controlled changes to be made in specifi c environmental factors. They can also provide the technical means to perform controlled studies aimed at understanding specifi c biological, chemical, or physical effects. Furthermore, bioreactors allow for a safe and reproducible production of tissue constructs. For later clinical applications, the bioreactor system should be an advantageous method in terms of low contamination risk, ease of handling, and scalability. With respect to drug screening, the main challenge is the effi cient, reproducible handling of a large quantity of tissue constructs in parallel (high-throughput screening). To date, the goals and expectations of bioreactor development have been fulfi lled only to some extent, as bioreactor design in tissue engineering is very complex and still at an early stage of development, especially for use in drug screening. In this chapter, important aspects of bioreactor design are summarized, and an overview of existing concepts is provided. An artifi cial immunosystem will be used as an example to demonstrate how an increased fundamental understanding of biological, biochemical, and engineering aspects can signifi cantly improve the properties of 3D tissue constructs. 2.1

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When the body is infected, it mounts an acute inflammatory response to rid itself of the pathogens and restore health. Uncontrolled acute inflammation due to infection is defined clinically as sepsis and can culminate in organ failure and death. We consider a threedimensional ordinary differential equation model of inflammation consisting of a pathogen, and two inflammatory mediators. The model reproduces the healthy outcome and diverse negative outcomes, depending on initial conditions and parameters. We analyze the various bifurcations between the different outcomes when key parameters are changed and suggest various therapeutic strategies. We suggest that the clinical condition of sepsis can arise from several distinct physiological states, each of which requires a different treatment approach. Published by Elsevier Ltd. Keywords: Systemic inflammation; Sepsis; Ordinary differential equation (ODE) models; Phase-space and bifurcation analysis

In this paper we review the trajectory of a model proposed by Stauffer and Weisbuch in 1992 to describe the evolution of the immune repertoire and present new results about its dynamical behavior. Ten years later this model, which is based on the ideas of the immune network as proposed by Jerne, has been able to describe a multi-connected network and could be used to reproduce immunization and aging experiments performed with mice. Besides its biological implications, the physical aspects of the complex dynamics of this network is very interesting per se. The immunization protocol is simulated by introducing small and large perturbations (damages), and in this work we discuss the role of both. In a very recent paper we studied the aging effects by using auto-correlation functions, and the results obtained apparently indicated that the small perturbations would be more important than the large ones, since their cumulative effects may change the attractor of the dynamics. However our new results indicate that both types of perturbations are important. It is the cooperative effects between both that lead to the complex behavior which allows to reproduce experimental results. 1 1

Mathematical modeling of MHC Class II mediated immune responses in tissues by