Recently, various process calculi have been introduced which are suited for the modelling of mobile computation and in particular the mobility of program code; a prominent example is the ambient calculus. Due to the complexity of the involved spatial reduction, there is — in contrast to the situation in standard process algebra — up to now no satisfying coalgebraic representation of a mobile process calculus. Here, we discuss a coalgebraic denotational semantics for the ambient calculus, viewed as a step towards a generic coalgebraic framework for modelling mobile systems. Crucial features of our modelling are a set of GSOS style transition rules for the ambient calculus, a hardwiring of the so-called hardening relation in the functorial signature, and a set-based treatment of hidden name sharing. The formal representation of this framework is cast in the algebraic-coalgebraic specification language CoCasl.