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Effect of DNase and Antibiotics on Biofilm Characteristics. Antimicrobial Agents and Chemotherapy
- School of Biology, Faculty of Applied Sciences MARA Technology University, Shah Alam 40450 Shah Alam, Selangor, Malaysia Email: fakharulzaman@salam.uitm.edu.my Tel: +60355444625, Fax: +60355444562 International Journal of Pharmacy and Biological Sciences
, 2009
"... The role of extracellular DNA in the maintenance of biofilms formed by gram-positive and gram-negative bacteria was studied. This study evaluated all the bacterial strains that were tested for the presence of extracellular DNA with an average size of 30 kb in the matrix. Our results indicate changes ..."
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The role of extracellular DNA in the maintenance of biofilms formed by gram-positive and gram-negative bacteria was studied. This study evaluated all the bacterial strains that were tested for the presence of extracellular DNA with an average size of 30 kb in the matrix. Our results indicate changes in community biomass, architecture, morphology, and the numbers of CFU in the presence of DNase. This effect seems to be common to biofilms established by various unrelated gram-positive and gram-negative bacteria. The cleavage of extracellular DNA leads to the formation of an altered biofilm that permits the increased penetration of antibiotics. Thus, the addition of DNase enhances the effect of antibiotics, resulting in decreased biofilm biomass and numbers of CFU. It is well known that bacteria form biofilms, in which they survive in the presence of high concentrations of antimicrobial
CONTENT ALERTS
, 2008
"... This article cites 62 articles, 25 of which can be accessed free ..."
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