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Self-engineering capabilities of bacteria
"... Under natural growth conditions, bacteria can utilize intricate communication capabilities (e.g. quorum-sensing, chemotactic signalling and plasmid exchange) to cooperatively form (self-organize) complex colonies with elevated adaptability—the colonial pattern is collectively engineered according to ..."
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Under natural growth conditions, bacteria can utilize intricate communication capabilities (e.g. quorum-sensing, chemotactic signalling and plasmid exchange) to cooperatively form (self-organize) complex colonies with elevated adaptability—the colonial pattern is collectively engineered according to the encountered environmental conditions. Bacteria do not genetically store all the information required for creating all possible patterns. Instead, additional information is cooperatively generated as required for the colonial selforganization to proceed. We describe how complex colonial forms (patterns) emerge through the communicationbased singular interplay between individual bacteria and the colony. Each bacterium is, by itself, a biotic autonomous system with its own internal cellular informatics capabilities (storage, processing and assessment of information). These afford the cell plasticity to select its response to biochemical messages it receives, including self-alteration and the broadcasting of messages to initiate alterations in other bacteria. Hence, new features can collectively emerge during self-organization from the intracellular level to the whole colony. The cells thus assume newly co-generated traits and abilities that are not explicitly stored in the genetic information of the individuals.
BioMed Central
, 2006
"... Research article Mariner mutagenesis of Brucella melitensis reveals genes with previously uncharacterized roles in virulence and survival ..."
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Research article Mariner mutagenesis of Brucella melitensis reveals genes with previously uncharacterized roles in virulence and survival
The Artistry of Bacterial Colonies and the Antibiotic Crisis
- in Coherent Structures in Complex Systems. Selected Papers of the XVII Sitges Conference on Statistical Mechanics. Edited by
, 2001
"... this paper we present the response of the colonial growth dynamics to the presence of antibiotics in various stressful conditions (For further details see [24]). In medicine, resistance to antibiotics is usually considered a qualitative property: either a specific strain of bacteria is resistant to ..."
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this paper we present the response of the colonial growth dynamics to the presence of antibiotics in various stressful conditions (For further details see [24]). In medicine, resistance to antibiotics is usually considered a qualitative property: either a specific strain of bacteria is resistant to a specific antibiotic or it is not. The bacteria are generally regarded as being `resistant' if they can tolerate the maximal concentration of the antibiotic which is non-toxic to the treated humans or animals. However, it is known that bacterial colonies are often more resistant than the individual cells, thereby blurring the borderline between resistance and sensitivity. Moreover, antibiotics affect cells differently depending on the growth and the physiological state of the cells. Our results show that susceptibility to antibiotic should be regarded as quantitative property: the bacteria react to antibiotic even in concentrations far below the critical effective concentrations that stop their growth.
Studies of Bacterial Cooperative Organization
"... Introduction During the course of evolution, bacteria have developed sophisticated cooperative behavior and intricate communication capabilities [1--3]. Utilizing these capabilities, bacterial colonies develop complex spatio-temporal patterns in response to adverse growth conditions. It is now unde ..."
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Introduction During the course of evolution, bacteria have developed sophisticated cooperative behavior and intricate communication capabilities [1--3]. Utilizing these capabilities, bacterial colonies develop complex spatio-temporal patterns in response to adverse growth conditions. It is now understood that the study of cooperative self-organization of bacterial colonies is an exciting new multidisciplinary field of research, necessitating the merger of biological information with the physics of non-equilibrium processes and the mathematics of non-linear dynamics. At this stage, several experimental systems have been identified, and preliminary modeling efforts are making significant progress in providing a framework for the understanding of experimental observations [4--12]. This endevour is not limited to bacteria alone. Studies have been performed of other types of microorganisms as well, such as amoeba [13] and yeast [14]. Fujikawa and Matsushita [5] reported for the fi
Adaptive Branching During Colonial Development of Lubricating Bacteria
"... this paper we use three groups of bacterial strains, all of which we initially isolated from plates containing Bacillus subtilis [11, 14, 38, 39]. The strains were subsequently identified as belonging to the BRANCHING OF BACTERIA 5 genera Paenibacillus. The strains display characteristic and distinc ..."
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this paper we use three groups of bacterial strains, all of which we initially isolated from plates containing Bacillus subtilis [11, 14, 38, 39]. The strains were subsequently identified as belonging to the BRANCHING OF BACTERIA 5 genera Paenibacillus. The strains display characteristic and distinct colonial morphologies and thus are characterized as three different morphotypes. We define morphotype as a group of bacteria exhibiting typical colonial patterns. Two strains belong to the same morphotype if under similar growth conditions they develop colonies of the same morphology for a range of growth conditions. Colonial growth patterns of a morphotype are inheritable and can be generated following inoculation with a single cell [2, 40] (note that this definition does not exclude the possibility that bacteria from different species will belong to the same morphotype, or that a specific species can belong to two different morphotypes depending on conditions).
Bacterial Cooperative Organization Under Antibiotic Stress
"... Bacteria have developed sophisticated modes of cooperative behavior to cope with unfavorable environmental conditions. Here we report the e#ect of antibiotic stress on the colonial development of Paenibacillus dendritiformis and P. vortex. We focus on the e#ect of co-trimoxazole on the colonial orga ..."
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Bacteria have developed sophisticated modes of cooperative behavior to cope with unfavorable environmental conditions. Here we report the e#ect of antibiotic stress on the colonial development of Paenibacillus dendritiformis and P. vortex. We focus on the e#ect of co-trimoxazole on the colonial organization of P. dendritiformis. We #nd that the exposure to non-lethal concentrations of antibiotic leads to dramatic changes in the colonial growth patterns. Branching, tip-splitting patterns are a#ected by reduction in the colonial fractal dimension from Df =2:0to 1:7, appearance of pronounced weak chirality and pronounced radial orientation of the growth. We combine the experimental observations with numerical studies of both discrete and continuous generic models to reveal the causes for the modi#cations in the patterns. We conclude that the bacteria adjust their chemotactic signaling together with variations in the bacteria length and increase in the metabolic load. c # 2000 Elsevier ...
Bacterial self-organization: co-enhancement of . . .
, 2003
"... During colonial development, bacteria generate a wealth of patterns, some of which are reminiscent of those occurring in abiotic systems. They can exhibit rich behaviour, reflecting informative communication capabilities that include exchange of genetic materials and the fact that the colony’s build ..."
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During colonial development, bacteria generate a wealth of patterns, some of which are reminiscent of those occurring in abiotic systems. They can exhibit rich behaviour, reflecting informative communication capabilities that include exchange of genetic materials and the fact that the colony’s building blocks are biotic. Each has internal degrees of freedom, informatic capabilities and freedom to respond by altering itself and others via emission of signals in a self-regulated manner. To unravel the special secrets of bacterial self-organization, we conducted an integrative (experimental and theoretical) study of abiotic and biotic systems. Guided by the notion of general biotic motives and principles, I propose that the informative communication between individuals makes possible the enhancement of the individuals’ regulated freedom, while increasing their cooperation. This process is accomplished via cooperative complexification of the colony through self-organization of hierarchical spatio-temporal patterning. The colonial higher complexity provides the degree of plasticity and flexibility required for better colonial adaptability and endurability in a dynamic environment. The biotic system can modify the environment and obtain environmental information for further self-improvement. I reflect on the potential applications of the new understanding on `engineered self-organization of systems too complex to design ’ and other issues.
Bacterial self-organization Self-Engineering Capabilities of Bacteria
"... Under natural growth conditions, bacteria can utilize intricate communication capabilities (e.g. quorum-sensing, chemotactic signaling and plasmid exchange) to cooperatively form (self-organize) complex colonies with elevated adaptability – the colonial pattern is collectively engineered according t ..."
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Under natural growth conditions, bacteria can utilize intricate communication capabilities (e.g. quorum-sensing, chemotactic signaling and plasmid exchange) to cooperatively form (self-organize) complex colonies with elevated adaptability – the colonial pattern is collectively engineered according to the encountered environmental conditions. Bacteria do not genetically store all the information required for creating all possible patterns. Instead, additional information is cooperatively generated as required for the colonial self-organization to proceed. We describe how complex colonial forms (patterns), emerge through the communication-based singular interplay between individual bacteria and the colony. Each bacterium is, by itself, a biotic autonomous system with its own internal cellular informatics capabilities (storage, processing and assessment of information). These afford the cell plasticity to select its response to biochemical messages it receives, including self-alteration and the broadcasting of messages to initiate alterations in other bacteria. Hence, new features can collectively emerge during self-organization from the intracellular level to the whole colony. The cells thus assume newly co-generated traits and abilities that are not explicitly stored in the genetic information of the individuals.
RESEARCH ARTICLE o d
"... All living beings find themselves embedded in a compli- pions of web-dwelling who spend most of their life with-Pátková et al. BMC Microbiology 2012, 12:178 ..."
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All living beings find themselves embedded in a compli- pions of web-dwelling who spend most of their life with-Pátková et al. BMC Microbiology 2012, 12:178
