Abstract In the current paper we present new empirical data and meta-analytic evidence for the role of dopamine-related genes as a susceptibility factor interacting with the rearing environment for better and for worse, that is, increasing children's susceptibility to both the adverse effects of unsupportive environments and the beneficial effects of supportive rearing. In Study 1 we examined the readiness of 91 7-year-old children to donate their money to a charity (UNICEF). We tested whether the association between attachment and donating behavior was moderated by the presence of the dopamine receptor D4 (DRD4) 7-repeat allele. The attachment story completion task was used to assess attachment as an index of the quality of the rearing environment. Children with secure attachment representations donated more but only if they had the DRD4 7-repeat allele. In Study 2 we present the results of a meta-analysis of geneenvironment studies on children up to 10 years of age involving dopamine-related genes (dopamine receptor D2, DRD4, dopamine transporter). The cumulative negative effects of these "risk genes" and adverse rearing environments have been stressed, but potentially cumulative positive effects of these same genes interacting with positive rearing environments remained largely unnoticed. We examined the associations between negative and positive rearing environments and developmental outcomes as moderated by dopamine-related gene polymorphisms. Children with the less efficient dopamine-related genes did worse in negative environments than the comparisons without the "genetic risk," but they also profited most from positive environments. Findings are discussed in light of evolutionary theory, and illustrated with some practical implications of differential susceptibility.

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University Medical Center Rotterdam, the

The quality of adolescents ’ relationships with peers can have a lasting impact on later psychosocial adjustment, mental health, and behavior. However, the effect of peer relations on later problem behavior is not uniformly strong, and genetic factors might influence this association. This study used four-wave longitudinal (11–19 years) data (n 1,151) from the Tracking Adolescents ’ Individual Lives Survey, a Dutch cohort study into adolescent development to test whether the dopamine receptor D4 polymorphism moderates the impact of negative (i.e., victimization) and positive peer experiences (i.e., social well-being) on later delinquency. Contrary to our expectations, results showed that carriers of the dopamine receptor D4 gene 4-repeat homozygous variant instead of those carrying the 7-repeat allele were more susceptible to the effects of both peer victimization and social well-being on delinquency later in adolescence. Findings of our study are discussed in light of other studies into genetic moderation of peer effects on adolescent development and the possibility that developmental specifics in adolescence, such as maturation processes in brain structure and functioning, may affect the interplay of environmental and genetic factors in this period in life. Despite substantial efforts into identifying malleable antece-dents and risks, adolescent delinquency continues to pose a burden to society. One of the most widely studied and stable risk factors for adolescent delinquency is the peer environ-ment. Two mechanisms have been proposed through which

Several studies have established that child interparental conflict evaluations link parent relationship functioning and adolescent adjust-ment. Using differential susceptibility theory and its vantage sensitivity complement as their framework, the authors examined differences between adolescents who vary in the DRD4 7 repeat genotype (i.e., 7+ vs. 7−) in how both interparental conflict and positivity affect ado-lescents ’ evaluations of interparental conflict

# The Author(s) 2012. This article is published with open access at Springerlink.com Abstract Asymmetric frontal brain activity has been widely implicated in reactions to emotional stimuli and is thought to reflect individual differences in approach–withdrawal motiva-tion. Here, we investigate whether asymmetric frontal activity, as a measure of approach–withdrawal motivation, also pre-dicts charitable donations after a charity’s (emotion-eliciting) promotional video showing a child in need is viewed, in a sample of 47 young adult women. In addition, we explore possibilities for mediation and moderation, by asymmetric frontal activity, of the effects of intranasally administered oxytocin and parental love withdrawal on charitable dona-tions. Greater relative left frontal activity was related to larger donations. In addition, we found evidence of moderation: Low levels of parental love withdrawal predicted larger don-ations in the oxytocin condition for participants showing greater relative right frontal activity. We suggest that when approach motivation is high (reflected in greater relative left frontal activity), individuals are generally inclined to take action upon seeing someone in need and, thus, to donate money to actively help out. Only when approach motivation is low (reflected in less relative left/greater relative right activity) do empathic concerns affected by oxytocin and experiences of love withdrawal play an important part in deciding about donations.

The effects of divorce on children’s behavioral development have proven to be quite varied across studies, and most developmental and family scholars today appreciate the great heterogeneity in divorce effects. Thus, this inquiry sought to determine whether select dopaminergic genes previously associated with externalizing behavior and/or found to moderate diverse environmental effects (dopamine receptors D2 and D4, catechol-O-methyltransferase) might moderate divorce effects on adolescent self-reported externalizing problems; and, if so, whether evidence of gene–environment (GE) interaction would prove consistent with diathesis–stress or differential-susceptibility models of environmental action. Data from the first and third wave of the Dutch Tracking Adolescents ’ Individual Lives Survey (n 1,134) revealed some evidence of GE interaction reflecting diathesis–stress but not differential susceptibility. It is intriguing that some evidence pointed to “vantage sensitivity, ” which are benefits accruing to those with a specific genotype when their parents remained together, the exact opposite of diathesis–stress. The limits of this work are considered, especially with regard to the conditions for testing differential susceptibility, and future directions are outlined. Exposure to divorce or the residential separation of (nonmar-ried) parents is a common experience of children growing up in the Western, industrialized world (Amato, 2010). Al-though it is difficult to establish exact numbers because of a variety of complicating reporting factors (Amato, 2010), it

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To promote optimal health and behavioral outcomes in children, nurses have long supported parents in providing the best possible care and nurturance to their offspring. A growing body of neuroscience research argues convincingly for the combined influences of genes and early caregiving on producing an individual’s unique health and behavioral phenotype. In this article, we systematically review studies that demonstrate the relationship between qualities of early caregiving and genetic propensity to health and behavioral outcomes. From an initial set of 255 articles, 24 articles met our inclusion criteria. The outcomes fall into four distinct groups: hypothalamic-pituitary-adrenal (HPA) response to stress, externalizing behavior, internalizing behavior, and disorganized attachment. In the articles, authors examined genes that code for the 5-hydroxy tryptamine (serotonin) transporter genes linked polymorphic region [5-HTTLPR] serotonin transporter promoter, D4 dopamine receptor, brain-derived neurotrophic factor, and monoamine oxidase A promoter. The reviewed studies suggest that the effect of the early rearing environment on gene expression relates mainly to HPA response to stress, whereas interactions between genes and caregiving mainly relate to behavior and attachment. Findings have implications for nurses focused on advocacy, prevention, and intervention to support the healthy development of children in families faced with adversity. Keywords epigenetics, gene expression, Gene-by-Environment interactions, early rearing environments, attachment In the study of human health and development, there has long been contention between those who ascribe behavioral outcomes to genes and those who ascribe them to environmen-tal influences. These two camps (known as nature and nurture, respectively) have often been construed as opposite poles in a continuum. However, a growing body of neuroscience research argues convincingly for an inclusive perspective wherein genes and the environment interact to produce a unique phenotype