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Results 1 - 10
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2,639
Evolutionary rate in the protein interaction network
- Science
"... High-throughput screens have begun to reveal the protein interaction network that underpins most cellular functions in the yeast Saccharomyces cerevisiae. How the organization of this network affects the evolution of the proteins that compose it is a fundamental question in molecular evolution. We s ..."
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Cited by 98 (0 self)
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show that the connectivity of well-conserved proteins in the network is negatively correlated with their rate of evolution. Proteins with more interactors evolve more slowly not because they are more important to the organism, but because a greater proportion of the protein is directly involved in its
A gene-coexpression network for global discovery of conserved genetic modules
- Science
, 2003
"... To elucidate gene function on a global scale, we identified pairs of genes that are coexpressed over 3182 DNA microarrays from humans, flies, worms, and yeast. We found 22,163 such coexpression relationships, each of which has been conserved across evolution. This conservation implies that the coexp ..."
Abstract
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Cited by 377 (5 self)
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To elucidate gene function on a global scale, we identified pairs of genes that are coexpressed over 3182 DNA microarrays from humans, flies, worms, and yeast. We found 22,163 such coexpression relationships, each of which has been conserved across evolution. This conservation implies
Characterization of a functionally important and evolutionarily well-conserved epitope mapped to the short consensus repeats of E-selectin and L-selectin
, 1992
"... Sdectins represent a new family of adhesion molecules, expressed by leukocytes and endothelial cells, that are involved in the regulation of leukocyte traffic. Here we have characterized a new monoclonal antibody (mAb) (EI.-246) that recognizes both human leukocyte I~selectin (previously called LAM- ..."
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Cited by 13 (1 self)
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-1, LECAM-1, or gpgOMEI:14) and endothelial cell E-sdectin (previously called ELAM-1). Eb246 recognized a 110-kD protein expressed on cells transfected with E-sdectin c.DNA and stained many postcapillary venules in inflamed human tonsil. EL-246 also stained human peripheral blood leukocytes
Sequence analysis Predicting DNA recognition by Cys2His2 zinc finger proteins
, 2008
"... Motivation: Cys2His2 zinc finger (ZF) proteins represent the largest class of eukaryotic transcription factors. Their modular structure and well-conserved protein–DNA interface allow the development of computational approaches for predicting their DNA-binding preferences even when no binding sites a ..."
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Motivation: Cys2His2 zinc finger (ZF) proteins represent the largest class of eukaryotic transcription factors. Their modular structure and well-conserved protein–DNA interface allow the development of computational approaches for predicting their DNA-binding preferences even when no binding sites
How well is enzyme function conserved as a function of pairwise sequence identity
- J. Mol. Biol
, 2003
"... Enzyme function conservation has been used to derive the threshold of sequence identity necessary to transfer function from a protein of known function to an unknown protein. Using pairwise sequence comparison, several studies suggested that when the sequence identity is above 40%, enzyme function i ..."
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Cited by 127 (15 self)
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Enzyme function conservation has been used to derive the threshold of sequence identity necessary to transfer function from a protein of known function to an unknown protein. Using pairwise sequence comparison, several studies suggested that when the sequence identity is above 40%, enzyme function
Evidence for a Golgi-to-Endosome Protein Sorting Pathway in Plasmodium falciparum
, 2014
"... During the asexual intraerythrocytic stage, the malaria parasite Plasmodium falciparum must traffic newly-synthesized proteins to a broad array of destinations within and beyond the parasite’s plasma membrane. In this study, we have localized two well-conserved protein components of eukaryotic endos ..."
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During the asexual intraerythrocytic stage, the malaria parasite Plasmodium falciparum must traffic newly-synthesized proteins to a broad array of destinations within and beyond the parasite’s plasma membrane. In this study, we have localized two well-conserved protein components of eukaryotic
SYMPOSIUM Evidence for the Local Evolution of Mechanisms Underlying Limb Regeneration in Salamanders
"... Synopsis The most extensive regenerative ability in adult vertebrates is found in the salamanders. Although it is often suggested that regeneration is an ancestral property for vertebrates, our studies on the cell-surface three-finger-protein Prod 1 provide clear evidence for the importance of local ..."
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of local evolution of limb regeneration in salamanders. Prod 1 is implicated in both patterning and growth in the regeneration of limbs. It interacts with well-conserved proteins such as the epidermal growth-factor receptor and the anterior gradient protein that are widely expressed in phylogeny. A
Review article Molecular chaperones and the aging process
, 2000
"... stress protein Molecular chaperones are abundant, well-conserved proteins responsible for the maintenance of the conformational homeostasis of cellular proteins and RNAs. Environmental stress is a proteotoxic insult to the cell, which leads to chaperone (heat shock protein, stress protein) induction ..."
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stress protein Molecular chaperones are abundant, well-conserved proteins responsible for the maintenance of the conformational homeostasis of cellular proteins and RNAs. Environmental stress is a proteotoxic insult to the cell, which leads to chaperone (heat shock protein, stress protein
ral ssBioMed CentBMC Evolutionary Biology Open AcceResearch article RPS4Y gene family evolution in primates
"... Backgound: The RPS4 gene codifies for ribosomal protein S4, a very well-conserved protein present in all kingdoms. In primates, RPS4 is codified by two functional genes located on both sex chromosomes: the RPS4X and RPS4Y genes. In humans, RPS4Y is duplicated and the Y chromosome therefore carries a ..."
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Backgound: The RPS4 gene codifies for ribosomal protein S4, a very well-conserved protein present in all kingdoms. In primates, RPS4 is codified by two functional genes located on both sex chromosomes: the RPS4X and RPS4Y genes. In humans, RPS4Y is duplicated and the Y chromosome therefore carries
132 4 Conclusions
"... Dna2 is a well-conserved protein from yeast to human, and we first demonstrate that Xenopus Dna2 is indeed a helicase-nuclease, as in yeast and human. Since previous work indicated a role for Dna2 in Xenopus DNA replication (Liu et al, 2000), the association of Dna2 with chromatin in S phase was fir ..."
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Dna2 is a well-conserved protein from yeast to human, and we first demonstrate that Xenopus Dna2 is indeed a helicase-nuclease, as in yeast and human. Since previous work indicated a role for Dna2 in Xenopus DNA replication (Liu et al, 2000), the association of Dna2 with chromatin in S phase
Results 1 - 10
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2,639
