that the extension mechanism satisfies the demands of outside developers who wish to incorporate new features. Two unusual extensions are presented: Multiscale, which adds the ability to visualize large-scale molecular assemblies such as viral coats, and Collaboratory, which allows researchers to share a Chimera

lateral sclerosis

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The coat protein gene from potato virus S (PVS) was introduced into Nicotiana debneyii by leaf disc trans-formation using Agrobacterium tumefaciens. Trans-genic plants expressing the viral coat protein were highly resistant o subsequent infection by the ME strain of PVS as indicated by an absence

coat protein. The most efficient inhibition was achieved by incubation with some anti-metatope MAbs known to bind to the TMV extremity that becomes disassembled first and contains the 5 " end of the RNA, as well as with some anti-cryptotope MAbs that bind only to dissociated coat protein subunits

The potential impact of transgenic plums and grapevines expressing viral coat protein (CP) gene constructs on the diversity and dynamics of virus populations was assessed under open and confined conditions in the frame of a research program sponsored by the European Commission. Across all field

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Previous studies have shown that most random amino acid substitutions destabilize protein folding (i.e. increase the folding free energy). No analogous studies have been carried out for protein-protein binding. Here we use a structure-based model of the major coat protein in a simple virus

contains at least two independent binding sites for viral

role in nematode-transmission: expression pattern and interaction with viral coat protein