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4,871
Identifying Recombination Hot Spots in the HIV-1 Genome
"... HIV-1 infection is characterized by the rapid generation of genetic diversity that facilitates viral escape from immune selection and antiretroviral therapy. Despite recombination’s crucial role in viral diversity and evolution, little is known about the genomic factors that influence recombination ..."
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between highly similar genomes. In this study, we use a minimally modified full-length HIV-1 genome and high-throughput sequence analysis to study recombination in gag and pol in T cells. We find that re-combination is favored at a number of recombination hot spots, where recombination occurs six times
Meiotic Recombination Hot Spot Activity at the HIS4 Locus of Saccharomyces cerevisiae
, 1996
"... cerevisiae. activity at the HIS4 locus of Saccharomyces sites and meiotic recombination hot spot Relationship between nuclease-hypersensitive ..."
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cerevisiae. activity at the HIS4 locus of Saccharomyces sites and meiotic recombination hot spot Relationship between nuclease-hypersensitive
Recombination Hot Spot in the Yeast Saccharomyces cerevisiae: Control in cis and trans
, 1994
"... trans. Saccharomyces cerevisiae: control in cis and the HIS4 recombination hot spot in the yeast Meiosis-specific double-strand DNA breaks at ..."
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trans. Saccharomyces cerevisiae: control in cis and the HIS4 recombination hot spot in the yeast Meiosis-specific double-strand DNA breaks at
The rise and fall of a human recombination hot spot
"... Human meiotic crossovers mainly cluster into narrow hot spots1 that profoundly influence patterns of haplotype diversity2 and which may also impact on genome instability3 and sequence evolution4-6. Hot spots also appear to be ephemeral7-9 but processes of hot-spot activation and their subsequent evo ..."
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evolutionary dynamics remain unknown. We now analyse the life cycle of a recombination hot spot. Sperm typing revealed a polymorphic hot spot that was activated in cis by a single base change, providing evidence for a primary sequence determinant necessary, though not sufficient, to activate recombination
Meiotic recombination hot spots and human DNA diversity
"... Meiotic recombination plays a key role in the maintenance of sequence diversity in the human genome. However, little is known about the fine-scale distribution and processes of recombination in human chro-mosomes, or how these impact on patterns of human diversity. We have therefore developed sperm ..."
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Cited by 6 (0 self)
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typing systems that allow human recombination to be analysed at very high resolution. The emerging picture is that human crossovers are far from randomly distributed but instead are targeted into very narrow hot spots that can profoundly influence patterns of haplotype diversity in the human genome
HUMHOT: a database of human meiotic recombination hot spots
, 2005
"... Meiotic recombination occurs preferentially at certain regions in the genome referred to as hot spots. The number of hot spots known in humans has increased manifold in recent years. The identif-ication of these hot spots in humans is of great inter-est to population and medical geneticists since th ..."
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Meiotic recombination occurs preferentially at certain regions in the genome referred to as hot spots. The number of hot spots known in humans has increased manifold in recent years. The identif-ication of these hot spots in humans is of great inter-est to population and medical geneticists since
DNase I-hypersensitive sites and transcription factor-binding motifs within the mouse Eb meiotic recombination hot spot
, 1991
"... The second intron of the Ep gene in the mouse major histocompatibiity complex is the site of a meiotic recombination hot spot. We detected two DNase I-hypersensitive sites in this intron in meiotic cells isolated from mouse testes. One site appears to be constitutive and is found in other tissues re ..."
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The second intron of the Ep gene in the mouse major histocompatibiity complex is the site of a meiotic recombination hot spot. We detected two DNase I-hypersensitive sites in this intron in meiotic cells isolated from mouse testes. One site appears to be constitutive and is found in other tissues
doi:10.1093/nar/gkp1251 Anatomy of mouse recombination hot spots
, 2009
"... Genome-wide analyses have suggested thousands of meiotic recombination hot spots across mammalian genomes. However, very few hot spots have been directly analyzed at a sub-kb scale for crossover (CO) activity. Using recombinant inbred strains as a CO library, here we report the identification and de ..."
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Cited by 3 (0 self)
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Genome-wide analyses have suggested thousands of meiotic recombination hot spots across mammalian genomes. However, very few hot spots have been directly analyzed at a sub-kb scale for crossover (CO) activity. Using recombinant inbred strains as a CO library, here we report the identification
Ribosomal DNA replication fork barrier and HOT1 recombination hot spot: shared sequences but independent activities
, 2000
"... In the ribosomal DNA of Saccharomyces cerevisiae, sequences in the nontranscribed spacer 3 * of the 35S ribosomal RNA gene are important to the polar arrest of replication forks at a site called the replication fork barrier (RFB) and also to the cis-acting, mitotic hyperrecombination site called HOT ..."
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HOT1. We have found that the RFB and HOT1 activity share some but not all of their essential sequences. Many of the mutations that reduce HOT1 recombination also decrease or eliminate fork arrest at one of two closely spaced RFB sites, RFB1 and RFB2. A simple model for the juxtaposition of RFB and HOT
Inhibition of the recBCDdependent activation of Chi recombinational hot spots in SOSinduced cells of Escherichia coli
- J
, 1992
"... Nucleotide sequences called Chi (5'-GCTGGTGG-3') enhance homologous recombination near their location by the RecBCD enzyme in Escherichia coli (Chi activation). A partial inhibition of Chi activation measured in A redgam mutant crosses was observed after treatment of wild-type cells with D ..."
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Cited by 9 (0 self)
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Nucleotide sequences called Chi (5'-GCTGGTGG-3') enhance homologous recombination near their location by the RecBCD enzyme in Escherichia coli (Chi activation). A partial inhibition of Chi activation measured in A redgam mutant crosses was observed after treatment of wild-type cells
Results 1 - 10
of
4,871
