-wide data sets. Discrimination between cleaved signal peptides and uncleaved N-terminal signal-anchor sequences is also possible, thoughwith lower precision. Predictions can be made on a publicly available WWW server. Present address: Novo Nordisk A/S, Scientific Computing, Building 9M1, Novo Alle, DK

This review is an updated and expanded version of two prior reviews that were published in this journal in 1997 and 2003. In the case of all approved agents the time frame has been extended to include the 25 1 /2 years from 01/1981 to 06/2006 for all diseases worldwide and from 1950 (earliest so

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selectively with the formation, stability, or function of the apical zonula adherens (ZA) and zonula occludens (ZO), or whether it would interfere with all forms of intercellular contact including the desmosomes. The effects of blocking antibodies and Fab fragments to uvomorulin on the formation

of the complexity and extreme dynamic range that characterize these samples (1). The widely adopted separative (survey) approach to proteomics, in which an attempt is made to detect all components, has proven to be limited in sensitivity toward low abundance proteins (2) and typically provides limited quantitative

-pathological findings, molecular assessment, treatment course and outcomes. Other cases from the literature showing co-existence of both disorders are also reviewed; to date 19 similar cases have been reported. Among all cases (including the present patient), eight cases were diagnosed with de novo MDS and NHL

, that distinguish driver pathways, or groups of genes containing driver mutations, from groups of genes with passenger mutations. We derive two algorithms, called Dendrix, to find driver pathways de novo from somatic mutation data. We apply Dendrix to analyze somatic mutation data from 623 genes in 188 lung

Hypertrophic cardiomyopathy occurs as an autosomal domi-nant familial disorder or as a sporadic disease without familial involvement. While missense mutations in the ft cardiac myosin heavy chain (MHC) gene account for approximately half of all cases of familial hypertrophic cardiomyopathy

We have shown previously that de novo methylation activities persist in mouse embryonic stem (ES) cells homozygous for a null mutation of Dnmt1 that encodes the major DNA cytosine methyltransferase. In this study, we have cloned a putative mammalian DNA methyltransferase gene, termed Dnmt2

propose an iterative de Bruijn graph approach iterating from small to large k capturing merits of all values in between. With real and simulated data, our IDBA algorithm is superior to all existing algorithms by constructing longer contigs with similar accuracy and using less memory. The running time