psychophysical and neurophysiological (single-unit and evoked-potential) findings, which provide some insight into how, and how well, the auditory system accomplishes this task. A survey of computational models designed to estimate multiple F0s and segregate concurrent sources is followed by a review

Abstract We have studied three members of a family (mother and two siblings) where the mother and father were first cousins and who presented a history of progressive mental deterioration, hyperkinetic extrapyramidal disorders, and epileptic seizures. They underwent the following examina-tions: cupremia, cupruria, and level of ceruloplasmin, genetic analysis for SCA1, 2, 3, 6, dentato-rubric-pallido-luysian atro-phy, and Huntington’s disease, electromyography (EMG), electroencephalography (EEG), brain magnetic resonance imaging (MRI), and investigation of acanthocytes with scan-ning electron microscopy. Genetic analysis was negative in all patients and acanthocytes were positive. EMG showed an axonal neuropathy in one sibling, EEG showed epileptiform activity in the two siblings, and MRI showed cortical atrophy in all subjects. This family shows the great variability of neu-

cal dysplasia during development in rats. Epilepsia 1999;40:

Low dose remedies are widely administered in medicine. We used Tele-Stereo-EEG and the hip-pocampal slice preparation to measure physiological effects of orally given Coffea D6 (40 mg/kg), Gelsemium D4 (10 mg/kg) and Veratrum D6 (30 mg/kg) in rats. Adult rats were implanted with electrodes positioned stereotactically into four brain regions. Changes in field potentials were transmitted wirelessly. After frequency analysis data from 6- 8 animals were averaged. For in vi-tro testing, preparations were superfused directly on hippocampal slices. Stimulation of Schaffer Collaterals by single stimuli (SS) or theta burst stimulation (TBS) resulted in stable population spike amplitudes. All three low dose preparations produced decreases of spectral power. Statisti-cally significant changes were observed in delta, theta and alpha2 spectral power. In the hippo-campal slice preparation Coffea facilitated signal transfer presumably by enhancing glutamate AMPA receptor transmission. Gelsemium showed a similar effect, but only after single shock stimulation. Opposite to this, attenuation of the electric pathway was recognized after theta burst stimulation due to AMPA receptor and glutamate metabotropic II receptor mediated transmission. Veratrum was able to attenuate glutamatergic due to receptor-mediated signalling sensitive to

in many computer vision applications and also in modeling biological vision, since recent neurophysiological evidence from the visual cortex of mammalian brains suggests that the filter response profiles of the main class of linearly-responding cortical neurons (called simple cells) are best modeled as a

you quite quickly what to choose. However, you cannot use the same simple emotional judgment when you are in the shoes of an economist trying to optimize the access to the locks on the Mississippi River. The task is to find a pricing structure that assures the most efficient and uninterrupted use

ABSTRACT: How do the structures of the medial temporal lobe contribute to memory? To address this question, we examine the neurophysiological correlates of both recognition and associative memory in the medial temporal lobe of humans, monkeys, and rats. These cross-species comparisons show

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methods have been applied to detect subclinical changes associated with exposures to developmental neurotoxicant in asymptomatic children. A review of neurophysiological findings in methylmercury neurotoxicity in children and adolescents suggested differences between the effects of prenatal

Abstract Historically, the locus coeruleus-norepinephrine (LC-NE) system has been implicated in arousal, but recent findings suggest that this system plays a more complex and specific role in the control of behavior than investigators previously thought. We review neurophysiological and modeling