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From genomics to chemical genomics: new developments in KEGG

by Minoru Kanehisa, Susumu Goto, Masahiro Hattori, Kiyoko F. Aoki-kinoshita, Masumi Itoh, Shuichi Kawashima, Toshiaki Katayama, Michihiro Araki, Mika Hirakawa - Nucleic Acids Res , 2006
"... The increasing amount of genomic and molecular information is the basis for understanding higherorder biological systems, such as the cell and the 15 organism, and their interactions with the environment, as well as for medical, industrial and other practical applications. The KEGG resource ..."
Abstract - Cited by 529 (30 self) - Add to MetaCart
The increasing amount of genomic and molecular information is the basis for understanding higherorder biological systems, such as the cell and the 15 organism, and their interactions with the environment, as well as for medical, industrial and other practical applications. The KEGG resource

Comparison of discrimination methods for the classification of tumors using gene expression data

by Sandrine Dudoit, Jane Fridlyand, Terence P. Speed - JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION , 2002
"... A reliable and precise classification of tumors is essential for successful diagnosis and treatment of cancer. cDNA microarrays and high-density oligonucleotide chips are novel biotechnologies increasingly used in cancer research. By allowing the monitoring of expression levels in cells for thousand ..."
Abstract - Cited by 770 (6 self) - Add to MetaCart
for thousands of genes simultaneously, microarray experiments may lead to a more complete understanding of the molecular variations among tumors and hence to a finer and more informative classification. The ability to successfully distinguish between tumor classes (already known or yet to be discovered) using

to Molecular Information

by Dowman P. Varn, James P. Crutchfield, D. P. Varn, J. P. Crutchfield, D. P. Varn, J. P. Crutchfield
"... rsta.royalsocietypublishing.org ..."
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rsta.royalsocietypublishing.org

Model Selection and Model Averaging in Phylogenetics: Advantages of Akaike Information Criterion and Bayesian Approaches Over Likelihood Ratio Tests

by David Posada, Thomas R. Buckley , 2004
"... Model selection is a topic of special relevance in molecular phylogenetics that affects many, if not all, stages of phylogenetic inference. Here we discuss some fundamental concepts and techniques of model selection in the context of phylogenetics. We start by reviewing different aspects of the sel ..."
Abstract - Cited by 407 (8 self) - Add to MetaCart
Model selection is a topic of special relevance in molecular phylogenetics that affects many, if not all, stages of phylogenetic inference. Here we discuss some fundamental concepts and techniques of model selection in the context of phylogenetics. We start by reviewing different aspects

Specificity and stability in topology of protein networks

by Sergei Maslov - Science , 2002
"... Molecular networks guide the biochemistry of a living cell on multiple levels: its metabolic and signalling pathways are shaped by the network of interacting proteins, whose production, in turn, is controlled by the genetic regulatory network. To address topological properties of these two networks ..."
Abstract - Cited by 408 (3 self) - Add to MetaCart
of experimental information about basic biochemical mechanisms of life, molecular networks operating in living cells are becoming better defined. Direct physical interactions between pairs of proteins

Molecular information technology

by Klaus-Peter Zauner - CR. REV. SOL. STATE , 2005
"... Molecular materials are endowed with unique properties of unrivaled potential for high density integration of computing systems. Present applications of molecules range from organic semiconductor materials for low-cost circuits to genetically modified proteins for commercial imaging equipment. To f ..."
Abstract - Cited by 10 (7 self) - Add to MetaCart
Molecular materials are endowed with unique properties of unrivaled potential for high density integration of computing systems. Present applications of molecules range from organic semiconductor materials for low-cost circuits to genetically modified proteins for commercial imaging equipment

Department of Molecular Information Processing

by The Graphically Oriented, John S. Mccaskill , 38
"... this article we present the molecular biology and chemical kinetics of two coupled systems which can serve as a platform for investigating optimization in other scenarios ..."
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this article we present the molecular biology and chemical kinetics of two coupled systems which can serve as a platform for investigating optimization in other scenarios

Biology and the flow of molecular information

by A J Libchaber
"... Abstract. The developments during the century in the physical understanding of biological activity are briefly discussed. ..."
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Abstract. The developments during the century in the physical understanding of biological activity are briefly discussed.

MR Diffusion Tensor Spectroscopy and Imaging

by Peter J. Basser, James Mattiello, Denis LeBihan , 1994
"... This paper describes a new NMR imaging modality-MR diffusion tensor imaging. It consists of estimating an effective diffusion tensor, Deff, within a voxel, and then displaying useful quantities derived from it. We show how the phenomenon of anisotropic diffusion of water (or metabolites) in anisotro ..."
Abstract - Cited by 384 (11 self) - Add to MetaCart
invariants of Deft, which are independent of the tissue's orientation in the laboratory frame of reference, reveal useful information about molecular mobility reflective of local microstructure and anatomy. Inherently, tensors (like De"f) describing transport processes in anisotropic media contain

Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. Part III: cellular and molecular clues to heart and arterial aging. Circulation

by Edward G. Lakatta, Daniel Levy, Edward G. Lakatta, Md Daniel Levy
"... The online version of this article, along with updated information and services, is located on the ..."
Abstract - Cited by 291 (2 self) - Add to MetaCart
The online version of this article, along with updated information and services, is located on the
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