Role of nonhistone proteins in the chromosomal events of

During the course of mitosis there are found a number of different movement phenomena and, although the anaphase movements of the chromosomes may appear as the most striking and spectacular event of mitosis, it must be borne in mind that anaphase is a continuation of the previous mitotic stages and that

We propose a fully-automated mitosis event detector using hidden conditional random fields for cell populations imaged with time-lapse phase contrast microscopy. The method consists of two stages that jointly optimize recall and precision. First, we apply model-based microscopy image

Abstract. We have used autoantibodies to probe the function of three human centromere proteins in mitosis. These antibodies recognize three human polypeptides in immunoblots: CENP-A (17 kD), CENP-B (80 kD), and CENP-C (140 kD). Purified anticentromere antibodies (ACA-IgG) disrupt mitosis when

Abstract—Time lapse microscopy has emerged as an important modality for studying human embryo development, as mitosis events can provide insight into embryo health and fate. Mi-tosis detection can happen through tracking of embryonic cells (tracking based), or from low level image features

Abstract. In budding yeast, a protein kinase called Gin4 is specifically activated during mitosis and functions in a pathway initiated by the Clb2 cyclin to control bud growth. We have used genetics and biochemistry to identify additional proteins that function with Gin4 in this pathway, and both

The processes of mitosis and cytokinesis in the multinucleate green alga Acrosiphonia have been examined in the light and electron microscopes. The course of events in division includes thickening of the chloroplast and migration of numerous nuclei and other cytoplasmic incusions to form a band

The mechanical events of mitosis depend on the action of microtubules and mitotic motors, but whether these spindle components act alone or in concert with a spindle matrix is an important question. Understanding the mechanism of mitosis is a problem that has fascinated and frustrated cell

DNA topoisomerases are highly specialized nuclear enzymes that perform topological changes in the DNA molecule in a very precise and unique fashion. Taking into account their fundamental roles in many events during DNA metabolism such as replication, transcription, recombination, condensation

Abstract—The aim of this paper is to detail the development of a novel tracking framework that is able to extract the cell motility indicators and to determine the cellular division (mitosis) events in large time-lapse phase-contrast image sequences. To address the challenges induced by non