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UDK 619:615.211 THE INFLUENCE OF LIDOCAINE AND BETA-BLOCKERS ON L-NAME-INDUCED POTENTIATION OF THE ISOLATED RAT HEMIDIAPHRAGM CONTRACTILITY
, 2005
"... L-NAME (1- 10 mM, 30 min of incubation) potentiates the tension developed (Td) in the isolated rat hemidiaphragm stimulated by direct subtetanic electrical stimulation (DSES) (F = 14 Hz). The aim of our study was to investigate the possible modulatory effect of local anaesthetic (lidocaine) and beta ..."
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L-NAME (1- 10 mM, 30 min of incubation) potentiates the tension developed (Td) in the isolated rat hemidiaphragm stimulated by direct subtetanic electrical stimulation (DSES) (F = 14 Hz). The aim of our study was to investigate the possible modulatory effect of local anaesthetic (lidocaine
Potentiation of phagocytosis of Bacteroides fragilis following incubation with clindamycin
- Journal of Antimicrobial Chemotherapy
, 1983
"... We studied the effect of clindamycin on phagocytosis of Bacteroides fragilis (MIC = 0-05 mg/1). In the in-vitro test system phagocytosis of Bact. fragilis was less than 11 % for the first 30min of incubation. At 60min, 25-50 % of Bact. fragilis were phagocytosed. At 90 min, phagocytosis increased to ..."
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Cited by 2 (0 self)
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We studied the effect of clindamycin on phagocytosis of Bacteroides fragilis (MIC = 0-05 mg/1). In the in-vitro test system phagocytosis of Bact. fragilis was less than 11 % for the first 30min of incubation. At 60min, 25-50 % of Bact. fragilis were phagocytosed. At 90 min, phagocytosis increased
Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes
- J. Cell
, 1983
"... ABSTRACT At 4°C transferrin bound to receptors on the reticulocyte plasma membrane, and at 37°C receptor-mediated endocytosis of transferrin occurred. Uptake at 37°C exceeded binding at 4°C by 2.5-fold and saturated after 20-30 min. During uptake at 37°C, bound transferrin was internalized into a tr ..."
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Cited by 81 (1 self)
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, into the extracellular space. At 37°C colloidal goldtransferrin (Auto clustered in coated pits and then appeared inside various intracellular membrane-bounded compartments. Small vesicles and tubules were labeled after short (5-10 min) incubations at 37°C. Larger multivesicular endosomes became heavily labeled after
Supplementary Experimental Procedures Preparation and Incubation of Hepatocytes
"... Hepatocytes were isolated from the livers of overnight-starved male Wistar rats (180–200 g) by collagenase digestion [S5]. The cells (50 mg/ml) were preincubated for 15 min at 37 � in 2 ml Krebs-Henseleit buffer containing 1 mM leucine in an atmosphere of O2/CO2 (95%/ 5%). [U-14C] leucine (0.25 �Ci/ ..."
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/ml) was added, and cells were either incubated for up to 30 min with the indicated concentration of AICA riboside or were submitted to a continuous flow of N2/CO2 (95%/ 5%). In some experiments, cells were preincubated for 15 min with rapamycin (300 nM). Following incubation, the cells were harvested
Calcium and Cyclic Nucleotide Regulation in Incubated Mouse Retinas
"... ABSTRACT When retinas from dark-adapted C57BL/6 mice were incubated in the dark for 5 rain at 37 ~ in Earle's medium, they contained 80-120 pmol/mg protein of cGMP and about 13 pmol/mg protein of cAMP. When the incubation in darkness was in calcium-deficient Earle's medium with 3 mM EGTA, ..."
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. Bright light after 2 min of dark incubation of darkadapted retinas resulted in a 40-50 % fall in cGMP, and bright light sharply reduced the elevated dark cGMP level of retinas in calcium-deficient media with 3 mM EDTA. However, no depression of normal dark levels of cGMP has thus far been obtained
A BIOCHEMICAL AND RADIOAUTOGRAPHIC S THYROID LOBES INCUBATED IN VITRO
"... In this study we analyzed several aspects of protein secretion by thyroid follicular cells. The study was carried out on intact thyroid lobes obtained from newborn rats and incubated in vitro. The fate of leucine 3H incorporated into protein within follicular cells of untreated and thyrotropic hormo ..."
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takes place via small vesicles which are intermingled among diverse small vesicles at the apex of the cells as well as in the Golgi region. Exposure of the lobes to TSH in the incubation medium for 45 or 90 min does not stimulate incorporation of leucine- 3H into protein. Acute stimulation with TSH does
IMPACT OF INCUBATION CONDITIONS ON BUFURALOL HUMAN CLEARANCE PREDICTIONS: ENZYME LABILITY AND NONSPECIFIC BINDING
"... This article is available online at http://dmd.aspetjournals.org ABSTRACT: Human liver microsomes (HLMs) are frequently utilized in drug discovery to predict the human clearance of a compound. The extent to which the incubation conditions affect the accuracy of a human clearance prediction was dete ..."
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was determined for bufuralol. HLMs were preincubated at 37°C for varying times (5-120 min) with and without NADPH, and the remaining enzyme activity was determined by incubating compounds that have been characterized to be selective for individual cytochromes P450 or flavin-containing monooxygenase 3. CYP2D6
Original Article Lovastatin Incubation Improves Acetylcholine-Induced Relaxation in Isolated Aortic Rings of Diabetic Rat
"... To evaluate the acute effect of lovastatin on diabetic endothelial dysfunction, we examined this effect on the aortic rings of streptozotocin-diabetic rats. The endothelial function was assessed in aortic rings isolated from diabetic rats, 12 weeks after treatment with streptozotocin (45 mg/kg, i.p. ..."
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with lovastatin (10-5 M) for 10 min, significantly improved the Ach-induced relaxation of diabetic groups and the maximum relaxation increased to 74.2 ±3.3 % (a 54 % increase, P<0.001). Incubation with NG –nitro-L-arginine methyl ester hydrochloride (L-NAME; 5x10-7 M) for 20 min eliminated a significant
Federal Republic of Germany. Summary
"... The effect of a combination of lithotripter shock waves and cytotoxic drugs was examined in vitro. L1210 cells in suspension were exposed to shock waves during incubation with cisplatin, doxurubicin, daunorubicin, THP-doxorubicin, or aclacinomycin. Proliferation was determined using the 3-4,5 dimeth ..."
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increased for the drugs with decreasing cytotoxicity. The effect of all five drugs was enhanced by shock waves to a higher degree at 7 min incubation as compared to 50 min incubation. The effect of cisplatin was most significantly enhanced, with a dose enhancement ratio of 6.7 at 7 min incubation
Photosensitization of lymphoblastoid cells with phthalocyanines at different saturating incubation times
- Cell Biol. Toxicol
, 1999
"... Abstract Photodynamic therapy of cancer is a promising treatment based on the tumor-speci¢c accumulation of photosensitizers followed by irradiation with visible light which induces tumor cell death. The e¡ect of di¡erent preincubation times on the photosensitization e¤ciency of the phthalocyanines ..."
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Cited by 3 (1 self)
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completely independent of the preincubation time (6 h vs. 24 h) with the phthalocyanine. When the cells were preincubated with 1 mmol/L AlPc for 10 min or 6 h, which allows the same accumulation of sensitizer by the cells, no signi¢cant e¡ect of the incubation time on the photodynamic inactivation of CCRF
Results 1 - 10
of
2,230
