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Sequence Logos: A New Way to Display Consensus Sequences
 Nucleic Acids Res
, 1990
"... INTRODUCTION A logo is "a single piece of type bearing two or more usually separate elements" [1]. In this paper, we use logos to display aligned sets of sequences. Sequence logos concentrate the following information into a single graphic [2]: 1. The general consensus of the sequences. ..."
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Cited by 650 (28 self)
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. National Cancer Institute, Frederick Cancer Research and Development Center, Laboratory of Mathematical Biology, P. O. Box B, Frederick, MD 21701. Internet addresses: toms@ncifcrf.gov and stephens@ncifcrf.gov. y corresponding author 1 2. The order of predominance of the residues at every position. 3
A new mathematical model for relative quantification in realtime RTPCR. Nucleic Acids Res
"... Use of the realtime polymerase chain reaction (PCR) to amplify cDNA products reverse transcribed from mRNA is on the way to becoming a routine tool in molecular biology to study low abundance gene expression. Realtime PCR is easy to perform, provides the necessary accuracy and produces reliable as ..."
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Cited by 1088 (4 self)
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Use of the realtime polymerase chain reaction (PCR) to amplify cDNA products reverse transcribed from mRNA is on the way to becoming a routine tool in molecular biology to study low abundance gene expression. Realtime PCR is easy to perform, provides the necessary accuracy and produces reliable
A Simple Model of Capital Market Equilibrium with Incomplete Information
 JOURNAL OF FINANCE
, 1987
"... The sphere of modern financial economics encompases finance, micro investment theory and much of the economics of uncertainty. As is evident from its influence on other branches of economics including public finance, industrial organization and monetary theory, the boundaries of this sphere are both ..."
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Cited by 756 (2 self)
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are both permeable and flexible. The complex interactions of time and uncertainty guarantee intellectual challenge and intrinsic excitement to the study of financial economics. Indeed, the mathematics of the subject contain some of the most interesting applications of probability and optimization theory
On the Selfsimilar Nature of Ethernet Traffic (Extended Version)
, 1994
"... We demonstrate that Ethernet LAN traffic is statistically selfsimilar, that none of the commonly used traffic models is able to capture this fractallike behavior, that such behavior has serious implications for the design, control, and analysis of highspeed, cellbased networks, and that aggrega ..."
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Cited by 2213 (46 self)
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, and that aggregating streams of such traffic typically intensifies the selfsimilarity (“burstiness”) instead of smoothing it. Our conclusions are supported by a rigorous statistical analysis of hundreds of millions of high quality Ethernet traffic measurements collected between 1989 and 1992, coupled with a
A semantics of multiple inheritance
 Information and Computation
, 1988
"... There are two major ways of structuring data in programming languages. The first and common one, used for example in Pascal, can be said to derive from standard branches of mathematics. Data is organized as cartesian products (i.e. record types), disjoint sums (i.e. unions or variant types) and func ..."
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Cited by 528 (9 self)
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There are two major ways of structuring data in programming languages. The first and common one, used for example in Pascal, can be said to derive from standard branches of mathematics. Data is organized as cartesian products (i.e. record types), disjoint sums (i.e. unions or variant types
A review of image denoising algorithms, with a new one
 SIMUL
, 2005
"... The search for efficient image denoising methods is still a valid challenge at the crossing of functional analysis and statistics. In spite of the sophistication of the recently proposed methods, most algorithms have not yet attained a desirable level of applicability. All show an outstanding perf ..."
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Cited by 508 (6 self)
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is proven to be asymptotically optimal under a generic statistical image model. The denoising performance of all considered methods are compared in four ways; mathematical: asymptotic order of magnitude of the method noise under regularity assumptions; perceptualmathematical: the algorithms artifacts
Modern Information Retrieval
, 1999
"... Information retrieval (IR) has changed considerably in the last years with the expansion of the Web (World Wide Web) and the advent of modern and inexpensive graphical user interfaces and mass storage devices. As a result, traditional IR textbooks have become quite outofdate which has led to the i ..."
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Cited by 3233 (29 self)
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to the introduction of new IR books recently. Nevertheless, we believe that there is still great need of a book that approaches the field in a rigorous and complete way from a computerscience perspective (in opposition to a usercentered perspective). This book is an effort to partially fulfill this gap and should
A gentle tutorial on the EM algorithm and its application to parameter estimation for gaussian mixture and hidden markov models
, 1997
"... We describe the maximumlikelihood parameter estimation problem and how the Expectationform of the EM algorithm as it is often given in the literature. We then develop the EM parameter estimation procedure for two applications: 1) finding the parameters of a mixture of Gaussian densities, and 2) fi ..."
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Cited by 693 (4 self)
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) finding the parameters of a hidden Markov model (HMM) (i.e., the BaumWelch algorithm) for both discrete and Gaussian mixture observation models. We derive the update equations in fairly explicit detail but we do not prove any convergence properties. We try to emphasize intuition rather than mathematical
Framing: toward clarification of a fractured paradigm’’,
 Journal of Communication
, 1993
"... In response to the proposition that communication lacks disciplinary status because of deficient core knowledge, I propose that we turn an ostensible weakness into a strength. We should identify our mission as bringing together insights and theories that would otherwise remain scattered in other di ..."
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Cited by 620 (1 self)
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in one location, communication can aspire to become a master discipline that synthesizes related theories and concepts and exposes them to the most rigorous, comprehensive statement and exploration. Reaching this goal would require a more selfconscious determination by communication scholars to plumb
Network Applications of Bloom Filters: A Survey
 INTERNET MATHEMATICS
, 2002
"... A Bloomfilter is a simple spaceefficient randomized data structure for representing a set in order to support membership queries. Bloom filters allow false positives but the space savings often outweigh this drawback when the probability of an error is controlled. Bloom filters have been used in ..."
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Cited by 522 (17 self)
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in database applications since the 1970s, but only in recent years have they become popular in the networking literature. The aim of this paper is to survey the ways in which Bloom filters have been used and modified in a variety of network problems, with the aim of providing a unified mathematical
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