Results 1 - 10 of 39,133

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

by T. R. Golub, D. K. Slonim, P. Tamayo, C. Huard, M. Gaasenbeek, J. P. Mesirov, H. Coller, M. L. Loh, J. R. Downing, M. A. Caligiuri, C. D. Bloomfield - Science , 1999
"... Although cancer classification has improved over the past 30 years, there has been no general approach for identifying new cancer classes (class discovery) or for assigning tumors to known classes (class prediction). Here, a generic approach to cancer classification based on gene expression monitori ..."
Abstract - Cited by 1779 (19 self) - Add to MetaCart
Although cancer classification has improved over the past 30 years, there has been no general approach for identifying new cancer classes (class discovery) or for assigning tumors to known classes (class prediction). Here, a generic approach to cancer classification based on gene expression

Linear models and empirical bayes methods for assessing differential expression in microarray experiments.

by Gordon K Smyth , Gordon K Smyth - Stat. Appl. Genet. Mol. Biol. , 2004
"... Abstract The problem of identifying differentially expressed genes in designed microarray experiments is considered. Lonnstedt and Speed (2002) derived an expression for the posterior odds of differential expression in a replicated two-color experiment using a simple hierarchical parametric model. ..."
Abstract - Cited by 1321 (24 self) - Add to MetaCart
Abstract The problem of identifying differentially expressed genes in designed microarray experiments is considered. Lonnstedt and Speed (2002) derived an expression for the posterior odds of differential expression in a replicated two-color experiment using a simple hierarchical parametric model

A training algorithm for optimal margin classifiers

by Bernhard E. Boser, et al. - PROCEEDINGS OF THE 5TH ANNUAL ACM WORKSHOP ON COMPUTATIONAL LEARNING THEORY , 1992
"... A training algorithm that maximizes the margin between the training patterns and the decision boundary is presented. The technique is applicable to a wide variety of classifiaction functions, including Perceptrons, polynomials, and Radial Basis Functions. The effective number of parameters is adjust ..."
Abstract - Cited by 1865 (43 self) - Add to MetaCart
is adjusted automatically to match the complexity of the problem. The solution is expressed as a linear combination of supporting patterns. These are the subset of training patterns that are closest to the decision boundary. Bounds on the generalization performance based on the leave-one-out method and the VC

Modeling and simulation of genetic regulatory systems: A literature review

by Hidde De Jong - JOURNAL OF COMPUTATIONAL BIOLOGY , 2002
"... In order to understand the functioning of organisms on the molecular level, we need to know which genes are expressed, when and where in the organism, and to which extent. The regulation of gene expression is achieved through genetic regulatory systems structured by networks of interactions between ..."
Abstract - Cited by 738 (14 self) - Add to MetaCart
In order to understand the functioning of organisms on the molecular level, we need to know which genes are expressed, when and where in the organism, and to which extent. The regulation of gene expression is achieved through genetic regulatory systems structured by networks of interactions between

Convolution Kernels on Discrete Structures

by David Haussler , 1999
"... We introduce a new method of constructing kernels on sets whose elements are discrete structures like strings, trees and graphs. The method can be applied iteratively to build a kernel on an infinite set from kernels involving generators of the set. The family of kernels generated generalizes the fa ..."
Abstract - Cited by 506 (0 self) - Add to MetaCart
the family of radial basis kernels. It can also be used to define kernels in the form of joint Gibbs probability distributions. Kernels can be built from hidden Markov random elds, generalized regular expressions, pair-HMMs, or ANOVA decompositions. Uses of the method lead to open problems involving

Statecharts: A Visual Formalism For Complex Systems

by David Harel , 1987
"... We present a broad extension of the conventional formalism of state machines and state diagrams, that is relevant to the specification and design of complex discrete-event systems, such as multi-computer real-time systems, communication protocols and digital control units. Our diagrams, which we cal ..."
Abstract - Cited by 2704 (56 self) - Add to MetaCart
. Statecharts are thus compact and expressive--small diagrams can express complex behavior--as well as compositional and modular. When coupled with the capabilities of computerized graphics, statecharts enable viewing the description at different levels of detail, and make even very large specifications

Algebraic laws for nondeterminism and concurrency

by Matthew Hennessy, Robin Milner - Journal of the ACM , 1985
"... Abstract. Since a nondeterministic and concurrent program may, in general, communicate repeatedly with its environment, its meaning cannot be presented naturally as an input/output function (as is often done in the denotational approach to semantics). In this paper, an alternative is put forth. Firs ..."
Abstract - Cited by 608 (13 self) - Add to MetaCart
Abstract. Since a nondeterministic and concurrent program may, in general, communicate repeatedly with its environment, its meaning cannot be presented naturally as an input/output function (as is often done in the denotational approach to semantics). In this paper, an alternative is put forth

Service Disciplines for Guaranteed Performance Service in Packet-Switching Networks

by Hui Zhang - Proceedings of the IEEE , 1995
"... While today’s computer networks support only best-effort service, future packet-switching integrated-services networks will have to support real-time communication services that allow clients to transport information with performance guarantees expressed in terms of delay, delay jitter, throughput, ..."
Abstract - Cited by 609 (4 self) - Add to MetaCart
While today’s computer networks support only best-effort service, future packet-switching integrated-services networks will have to support real-time communication services that allow clients to transport information with performance guarantees expressed in terms of delay, delay jitter, throughput

Symbolic Model Checking: 10^20 States and Beyond

by J. R. Burch, E. M. Clarke, K. L. McMillan, D. L. Dill, L. J. Hwang , 1992
"... Many different methods have been devised for automatically verifying finite state systems by examining state-graph models of system behavior. These methods all depend on decision procedures that explicitly represent the state space using a list or a table that grows in proportion to the number of st ..."
Abstract - Cited by 758 (41 self) - Add to MetaCart
of states. We describe a general method that represents the state space symbolical/y instead of explicitly. The generality of our method comes from using a dialect of the Mu-Calculus as the primary specification language. We describe a model checking algorithm for Mu-Calculus formulas that uses Bryant’s

Dynamic Bayesian Networks: Representation, Inference and Learning

by Kevin Patrick Murphy , 2002
"... Modelling sequential data is important in many areas of science and engineering. Hidden Markov models (HMMs) and Kalman filter models (KFMs) are popular for this because they are simple and flexible. For example, HMMs have been used for speech recognition and bio-sequence analysis, and KFMs have bee ..."
Abstract - Cited by 770 (3 self) - Add to MetaCart
been used for problems ranging from tracking planes and missiles to predicting the economy. However, HMMs and KFMs are limited in their “expressive power”. Dynamic Bayesian Networks (DBNs) generalize HMMs by allowing the state space to be represented in factored form, instead of as a single discrete
Results 1 - 10 of 39,133