for model-based clustering that provides a principled statistical approach to these issues. We also show that this can be useful for other problems in multivariate analysis, such as discriminant analysis and multivariate density estimation. We give examples from medical diagnosis, mineeld detection, cluster

This paper presents the fundamental principles underlying tabu search as a strategy for combinatorial optimization problems. Tabu search has achieved impressive practical successes in applications ranging from scheduling and computer channel balancing to cluster analysis and space planning

) evaluating an individual’s fitness dependent on the number of external nondominated points that dominate it, c) preserving population diversity using the Pareto dominance relationship, and d) incorporating a clustering procedure in order to reduce the nondominated set without destroying its characteristics

Similarity plays a fundamental role in theories of knowledge and behavior. It serves as an organizing principle by which individuals classify objects, form concepts, and make generalizations. Indeed, the concept of similarity is ubiquitous in psychological theory. It underlies the accounts

this to five percent. In principle a pairs cluster bootstrap should work well, but in practice a wild cluster bootstrap performs better.

We propose a principled account on multiclass spectral clustering. Given a discrete clustering formulation, we first solve a relaxed continuous optimization problem by eigendecomposition. We clarify the role of eigenvectors as a generator of all optimal solutions through orthonormal transforms. We

such supervision. Such methods use the constraints to either modify the objective function, or to learn the distance measure. We propose a probabilistic model for semisupervised clustering based on Hidden Markov Random Fields (HMRFs) that provides a principled framework for incorporating supervision into prototype

) distance-function learning methods that adapt the underlying similarity metric used by the clustering algorithm. This paper provides new methods for the two approaches as well as presents a new semi-supervised clustering algorithm that integrates both of these techniques in a uniform, principled

Cutting up a complex object into simpler sub-objects is a fundamental problem in various disciplines. In image processing, images are segmented while in computational geometry, solid polyhedra are decomposed. In recent years, in computer graphics, polygonal meshes are decomposed into sub-meshes. In this paper we propose a novel hierarchical mesh decomposition algorithm. Our algorithm computes a decomposition into the meaningful components of a given mesh, which generally refers to segmentation at regions of deep concavities. The algorithm also avoids over-segmentation and jaggy boundaries between the components. Finally, we demonstrate the utility of the algorithm in control-skeleton extraction.

We have expanded our reference set of proteins used in the estimation of protein secondary structure by CD spectroscopy from 29 to 37 proteins by including 3 additional globular proteins with known X-ray structure and 5 denatured proteins. We have also modified the self-consistent method for analyzing protein CD spectra, SELCON3, by including a new selection criterion