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91,455
A Spatial Logic based on Regions and Connection
 PROCEEDINGS 3RD INTERNATIONAL CONFERENCE ON KNOWLEDGE REPRESENTATION AND REASONING
, 1992
"... We describe an interval logic for reasoning about space. The logic simplifies an earlier theory developed by Randell and Cohn, and that of Clarke upon which the former was based. The theory supports a simpler ontology, has fewer defined functions and relations, yet does not suffer in terms of its us ..."
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Cited by 745 (32 self)
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We describe an interval logic for reasoning about space. The logic simplifies an earlier theory developed by Randell and Cohn, and that of Clarke upon which the former was based. The theory supports a simpler ontology, has fewer defined functions and relations, yet does not suffer in terms of its
Factor Graphs and the SumProduct Algorithm
 IEEE TRANSACTIONS ON INFORMATION THEORY
, 1998
"... A factor graph is a bipartite graph that expresses how a "global" function of many variables factors into a product of "local" functions. Factor graphs subsume many other graphical models including Bayesian networks, Markov random fields, and Tanner graphs. Following one simple c ..."
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Cited by 1791 (69 self)
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A factor graph is a bipartite graph that expresses how a "global" function of many variables factors into a product of "local" functions. Factor graphs subsume many other graphical models including Bayesian networks, Markov random fields, and Tanner graphs. Following one simple
Modeling and simulation of genetic regulatory systems: A literature review
 JOURNAL OF COMPUTATIONAL BIOLOGY
, 2002
"... In order to understand the functioning of organisms on the molecular level, we need to know which genes are expressed, when and where in the organism, and to which extent. The regulation of gene expression is achieved through genetic regulatory systems structured by networks of interactions between ..."
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Cited by 738 (14 self)
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In order to understand the functioning of organisms on the molecular level, we need to know which genes are expressed, when and where in the organism, and to which extent. The regulation of gene expression is achieved through genetic regulatory systems structured by networks of interactions between
Symbolic Model Checking for Realtime Systems
 INFORMATION AND COMPUTATION
, 1992
"... We describe finitestate programs over realnumbered time in a guardedcommand language with realvalued clocks or, equivalently, as finite automata with realvalued clocks. Model checking answers the question which states of a realtime program satisfy a branchingtime specification (given in an ..."
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Cited by 578 (50 self)
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in an extension of CTL with clock variables). We develop an algorithm that computes this set of states symbolically as a fixpoint of a functional on state predicates, without constructing the state space. For this purpose, we introduce a calculus on computation trees over realnumbered time. Unfortunately
Clustering Gene Expression Patterns
, 1999
"... Recent advances in biotechnology allow researchers to measure expression levels for thousands of genes simultaneously, across different conditions and over time. Analysis of data produced by such experiments offers potential insight into gene function and regulatory mechanisms. A key step in the ana ..."
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Cited by 451 (11 self)
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Recent advances in biotechnology allow researchers to measure expression levels for thousands of genes simultaneously, across different conditions and over time. Analysis of data produced by such experiments offers potential insight into gene function and regulatory mechanisms. A key step
SELF: The power of simplicity
, 1991
"... SELF is an objectoriented language for exploratory programming based on a small number of simple and concrete ideas: prototypes, slots, and behavior. Prototypes combine inheritance and instantiation to provide a framework that is simpler and more flexible than most objectoriented languages. Slots ..."
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Cited by 640 (19 self)
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. Slots unite variables and procedures into a single construct. This permits the inheritance hierarchy to take over the function of lexical scoping in conventional languages. Finally, because SELF does not distinguish state from behavior, it narrows the gaps between ordinary objects, procedures
Statecharts: A Visual Formalism For Complex Systems
, 1987
"... We present a broad extension of the conventional formalism of state machines and state diagrams, that is relevant to the specification and design of complex discreteevent systems, such as multicomputer realtime systems, communication protocols and digital control units. Our diagrams, which we cal ..."
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Cited by 2704 (56 self)
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. Statecharts are thus compact and expressivesmall diagrams can express complex behavioras well as compositional and modular. When coupled with the capabilities of computerized graphics, statecharts enable viewing the description at different levels of detail, and make even very large specifications
Algebraic laws for nondeterminism and concurrency
 Journal of the ACM
, 1985
"... Abstract. Since a nondeterministic and concurrent program may, in general, communicate repeatedly with its environment, its meaning cannot be presented naturally as an input/output function (as is often done in the denotational approach to semantics). In this paper, an alternative is put forth. Firs ..."
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Cited by 608 (13 self)
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Abstract. Since a nondeterministic and concurrent program may, in general, communicate repeatedly with its environment, its meaning cannot be presented naturally as an input/output function (as is often done in the denotational approach to semantics). In this paper, an alternative is put forth
Convolution Kernels on Discrete Structures
, 1999
"... We introduce a new method of constructing kernels on sets whose elements are discrete structures like strings, trees and graphs. The method can be applied iteratively to build a kernel on an infinite set from kernels involving generators of the set. The family of kernels generated generalizes the fa ..."
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Cited by 506 (0 self)
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the family of radial basis kernels. It can also be used to define kernels in the form of joint Gibbs probability distributions. Kernels can be built from hidden Markov random elds, generalized regular expressions, pairHMMs, or ANOVA decompositions. Uses of the method lead to open problems involving
Alternative isoform regulation in human tissue transcriptomes
 Nature
, 2008
"... Through alternative processing of premRNAs, individual mammalian genes often produce multiple mRNA and protein isoforms that may have related, distinct or even opposing functions. Here we report an indepth analysis of 15 diverse human tissue and cell line transcriptomes based on deep sequencing of ..."
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Cited by 545 (6 self)
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Through alternative processing of premRNAs, individual mammalian genes often produce multiple mRNA and protein isoforms that may have related, distinct or even opposing functions. Here we report an indepth analysis of 15 diverse human tissue and cell line transcriptomes based on deep sequencing
Results 11  20
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