sequence analyses rapidly and reproducibly is generally missing. In order to quantify the accuracy and reproducibility of function assignments on a genome-wide scale, we have re-annotated the entire genome sequence of Chlamydia trachomatis (serovar D), in a collaborative manner. Results: We have encoded

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Summary: GenAlyzer is a software tool designed for the interactive visualization of sequence matches between DNA or protein sequences. It provides visualizations on different levels of granularity, from complete overviews via zoomed regions to alignments of particular matching substrings. GenAlyzer can efficiently handle very large datasets, allowing to display tens of thousands of matches between sequences of tens of millions of bases. Availability: GenAlyzer is available free of charge for non-commercial research institutions. For more details, see

Abstract We have previously shown that the detection of gene fusion events can contribute towards the elucidation of functional associations of proteins within entire genomes. Here we have analysed the entire genome of Drosophila melanogaster using fusion analysis and two additional constraints

for the entire genome of several individuals enabling scientists to conduct genome-wide comparisons between several individuals or several population samples, and ask comprehensive questions regarding the nature of genetic variation in extant populations and the evolutionary forces in the population’s history

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these hypotheses, we sequenced entire mtDNA genomes in the largest series of patients suffering from Ras/MAPK pathway syndromes analyzed to date (n = 45), most of them classified as NS patients (n = 42). Methods/Principal Findings: The results indicate that the observed mtDNA lineages were mostly of European

Conserved domains in proteins are one of the major sources of functional information for experimental design and genome-level annotation. Though search tools for conserved domain databases such as Hidden Markov Models (HMMs) are sensitive in detecting conserved domains in proteins when they share

Abstract. The resurgence of Chikungunya virus (CHIKV) in the southern, northeastern and northern parts of Thailand, inflicting approximately 46,000 reported cases since October 2008 until December 2009, has raised public health concerns. In the present study, we characterized nearly complete genome

Abstract.-In 2004, an H4N6 subtype avian influenza virus (AIV) was isolated from mallard ducks (Anas platyrhynchos) in Zhalong Nature Reserve of Heilongjiang Province in China. The virus was named A/Mallard/Zhalong/88/04(H4N6) (MZL88/04). In this study, eight gene segments of MZL88/04 were amplified by reverse transcription polymerase chain reaction (RT-PCR). Nucleotide and deduced amino acid sequence homology and phylogenetic relationships were determined between MZL88/04 and other H4N6 subtype isolates. Isolate MZL88/04 was classified into the Eurasian lineage, and was closely related to isolates from Nanchang, indicating close evolutionary relationships between the genes studied. To our knowledge, this is the first report of an H4N6 subtype AIV strain isolated from wild birds in the mainland of China.