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Alternative isoform regulation in human tissue transcriptomes

by Eric T. Wang, Rickard S, Shujun Luo, Irina Khrebtukova, Lu Zhang, Christine Mayr, Stephen F. Kingsmore, Gary P. Schroth, Christopher B. Burge - Nature , 2008
"... Through alternative processing of pre-mRNAs, individual mammalian genes often produce multiple mRNA and protein isoforms that may have related, distinct or even opposing functions. Here we report an in-depth analysis of 15 diverse human tissue and cell line transcriptomes based on deep sequencing of ..."
Abstract - Cited by 545 (6 self) - Add to MetaCart
Through alternative processing of pre-mRNAs, individual mammalian genes often produce multiple mRNA and protein isoforms that may have related, distinct or even opposing functions. Here we report an in-depth analysis of 15 diverse human tissue and cell line transcriptomes based on deep sequencing

Real-Time Obstacle Avoidance for Manipulators and Mobile Robots

by Oussama Khatib - INT. JOUR OF ROBOTIC RESEARCH , 1986
"... This paper presents a unique real-time obstacle avoidance approach for manipulators and mobile robots based on the artificial potential field concept. Collision avoidance, tradi-tionally considered a high level planning problem, can be effectively distributed between different levels of control, al- ..."
Abstract - Cited by 1345 (28 self) - Add to MetaCart
This paper presents a unique real-time obstacle avoidance approach for manipulators and mobile robots based on the artificial potential field concept. Collision avoidance, tradi-tionally considered a high level planning problem, can be effectively distributed between different levels of control, al

Human DNA methylomes at base resolution show widespread epigenomic differences.

by Ryan Lister , Mattia Pelizzola , Robert H Dowen , R David Hawkins , Gary Hon , Julian Tonti-Filippini , Joseph R Nery , Leonard Lee , Zhen Ye , Que-Minh Ngo , Lee Edsall , Jessica Antosiewicz-Bourget , Ron Stewart , Victor Ruotti , A Harvey Millar , James A Thomson , Bing Ren , Joseph R Ecker - Nature, , 2009
"... DNA cytosine methylation is a central epigenetic modification that has essential roles in cellular processes including genome regulation, development and disease. Here we present the first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryo ..."
Abstract - Cited by 401 (6 self) - Add to MetaCart
passed since it was proposed that cytosine DNA methylation in eukaryotes could act as a stably inherited modification affecting gene regulation and cellular differentiation Single-base-resolution maps of DNA methylation for two human cell lines Single-base DNA methylomes of the flowering plant

SKETCH: An Interface for Sketching 3D Scenes

by Robert C. Zeleznik, Kenneth P. Herndon, John F. Hughes , 1996
"... Sketching communicates ideas rapidly through approximate visual images with low overhead (pencil and paper), no need for precision or specialized knowledge, and ease of low-level correction and revision. In contrast, most 3D computer modeling systems are good at generating arbitrary views of precise ..."
Abstract - Cited by 320 (22 self) - Add to MetaCart
-photorealistic rendering and a purely gestural interface based on simplified line drawings of primitives that allows all operations to be specified within the 3D world.

Developments in the Measurement of Subjective Well-Being

by Daniel Kahneman , Alan B Krueger - Psychological Science. , 1993
"... F or good reasons, economists have had a long-standing preference for studying peoples' revealed preferences; that is, looking at individuals' actual choices and decisions rather than their stated intentions or subjective reports of likes and dislikes. Yet people often make choices that b ..."
Abstract - Cited by 284 (7 self) - Add to MetaCart
that bear a mixed relationship to their own happiness. A large literature from behavioral economics and psychology finds that people often make inconsistent choices, fail to learn from experience, exhibit reluctance to trade, base their own satisfaction on how their situation compares with the satisfaction

Kalman Filter-based Algorithms for Estimating Depth from Image Sequences

by Larry Matthies, Takeo Kanade, Richard Szeliski , 1989
"... Using known camera motion to estimate depth from image sequences is an important problem in robot vision. Many applications of depth-from-motion, including navigation and manipulation, require algorithms that can estimate depth in an on-line, incremental fashion. This requires a representation that ..."
Abstract - Cited by 259 (26 self) - Add to MetaCart
Using known camera motion to estimate depth from image sequences is an important problem in robot vision. Many applications of depth-from-motion, including navigation and manipulation, require algorithms that can estimate depth in an on-line, incremental fashion. This requires a representation

McRT-STM: a High Performance Software Transactional Memory System for a Multi-Core Runtime

by Bratin Saha, Ali-reza Adl-tabatabai, Richard L. Hudson, Chi Cao Minh, Benjamin Hertzberg - In Proc. of the 11th ACM Symp. on Principles and Practice of Parallel Programming , 2006
"... Applications need to become more concurrent to take advantage of the increased computational power provided by chip level multiprocessing. Programmers have traditionally managed this concurrency using locks (mutex based synchronization). Unfortunately, lock based synchronization often leads to deadl ..."
Abstract - Cited by 241 (14 self) - Add to MetaCart
, and cache line based versus object based conflict detection. We also show a MCAS implementation that works on arbitrary values, coexists with the STM, and can be used as a more efficient form of transactional memory. To provide a baseline we compare the performance of the STM with that of fine

Detection of Logical Coupling Based on Product Release History

by Harald Gall, Karin Hajek, Mehdi Jazayeri , 1998
"... Code-based metrics such as coupling and cohesion are used to measure a system’s structural complexity. But dealing with large systems—those consisting of several millions of lines — at the code level faces many problems. An alternative approach is to concentrate on the system’s building blocks such ..."
Abstract - Cited by 208 (13 self) - Add to MetaCart
Code-based metrics such as coupling and cohesion are used to measure a system’s structural complexity. But dealing with large systems—those consisting of several millions of lines — at the code level faces many problems. An alternative approach is to concentrate on the system’s building blocks

Automatic Extraction of Tempo and Beat from Expressive Performances

by Simon Dixon - Journal of New Music Research , 2001
"... We describe a computer program which is able to estimate the tempo and the times of musical beats in expressively performed music. The input data may be either digital audio or a symbolic representation of music such as MIDI. The data is processed off-line to detect the salient rhythmic events and t ..."
Abstract - Cited by 193 (27 self) - Add to MetaCart
and the timing of these events is analysed to generate hypotheses of the tempo at various metrical levels. Based on these tempo hypotheses, a multiple hypothesis search nds the sequence of beat times which has the best fit to the rhythmic events. We show that estimating the perceptual salience of rhythmic events

The UCSC table browser data retrieval tool

by Donna Karolchik, Angela S. Hinrichs, Terrence S. Furey, Krishna M. Roskin, Charles W. Sugnet, David Haussler, W. James Kent - Nucleic Acids Res , 2004
"... hgText) provides text-based access to a large collection of genome assemblies and annotation data stored in the Genome Browser Database. A ¯exible alternative to the graphical-based Genome Browser, this tool offers an enhanced level of query support that includes restrictions based on ®eld values, f ..."
Abstract - Cited by 187 (18 self) - Add to MetaCart
hgText) provides text-based access to a large collection of genome assemblies and annotation data stored in the Genome Browser Database. A ¯exible alternative to the graphical-based Genome Browser, this tool offers an enhanced level of query support that includes restrictions based on ®eld values
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