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Results 1 - 10
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6,734
Loopy belief propagation for approximate inference: An empirical study. In:
- Proceedings of Uncertainty in AI,
, 1999
"... Abstract Recently, researchers have demonstrated that "loopy belief propagation" -the use of Pearl's polytree algorithm in a Bayesian network with loops -can perform well in the context of error-correcting codes. The most dramatic instance of this is the near Shannon-limit performanc ..."
Abstract
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Cited by 676 (15 self)
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that loopy propagation can also work well for graphs with many small loops. At the same time, our experimental results suggest a cautionary note about loopy propagation, showing that the marginals may exhibit oscillations that have very little correlation with the correct marginals. We presented some
Atomic resolution structures of the core domain of avian sarcoma virus integrase and its D64N mutant
- Biochemistry
, 1999
"... ABSTRACT: Six crystal structures of the core domain of integrase (IN) from avian sarcoma virus (ASV) and its active-site derivative containing an Asp64 f Asn substitution have been solved at atomic resolution ranging 1.02-1.42 Å. The high-quality data provide new structural information about the act ..."
Abstract
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Cited by 6 (2 self)
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H-dependent conformational changes of the active-site loop correlates with the pH vs activity profile observed for ASV IN. Retroviruses, such as human immunodeficiency virus type 1 (HIV-1)1 or avian sarcoma virus (ASV), encode in their genes three essential enzymes: reverse transcriptase (RT), protease (PR), and integrase
The Mobility of an HIV-1 Integrase Active Site Loop Is Correlated with Catalytic Activity
- Biochemistry
, 1999
"... ABSTRACT: Replication of HIV-1 requires the covalent integration of the viral cDNA into the host chromosomal DNA directed by the virus-encoded integrase protein. Here we explore the importance of a protein surface loop near the integrase active site using protein engineering and X-ray crystallograph ..."
Abstract
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Cited by 35 (4 self)
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ABSTRACT: Replication of HIV-1 requires the covalent integration of the viral cDNA into the host chromosomal DNA directed by the virus-encoded integrase protein. Here we explore the importance of a protein surface loop near the integrase active site using protein engineering and X
First-order incremental block-based statistical timing analysis
- In DAC
, 2004
"... Variability in digital integrated circuits makes timing verification an extremely challenging task. In this paper, a canonical first order delay model is proposed that takes into account both correlated and independent randomness. A novel linear-time block-based statistical timing algorithm is emplo ..."
Abstract
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Cited by 193 (6 self)
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Variability in digital integrated circuits makes timing verification an extremely challenging task. In this paper, a canonical first order delay model is proposed that takes into account both correlated and independent randomness. A novel linear-time block-based statistical timing algorithm
active-site environment and the dimer stability of (pro)caspase 3
, 2005
"... Ionic interactions near loop L4 are important for maintaining the active site environment and the dimer stability of (pro)caspase-3 ..."
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Ionic interactions near loop L4 are important for maintaining the active site environment and the dimer stability of (pro)caspase-3
doi:10.4061/2011/939068 Research Article Asp295 Stabilizes the Active-Site Loop Structure of
, 2010
"... Copyright © 2011 Tripty A. Hirani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We have developed an in vitro system for det ..."
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loop structure of E1α, is phosphorylated. In addition to Ser292, Asp295 and Gly297 are highly conserved in the E1α active-site loop sequences. Mutation of Asp295 to Ala, Asn, or Leu greatly reduced phosphorylation of Ser292, while mutation of Gly297 had relatively little effect. Quantitative two
The Conserved Active-Site Loop Residues of Ferrochelatase Induce Porphyrin Conformational Changes Necessary for Catalysis†
, 2005
"... ABSTRACT: Binding of porphyrin to murine ferrochelatase, the terminal enzyme of the heme biosynthetic pathway, is investigated by employing a set of variants harboring mutations in a putative porphyrin-binding loop. Using resonance Raman (RR) spectroscopy, the structural properties of the ferrochela ..."
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of the ferrochelatase-bound porphyrins are examined, especially with respect to the porphyrin deformation occurring in the environment of the active site. This deformation is thought to be a key step in the enzymatic insertion of ferrous iron into the porphyrin ring to make heme. Our previous RR spectroscopic studies
Localization of brain electrical activity via linearly constrained minimum variance spatial filtering
- IEEE Trans. Biomed. Eng
, 1997
"... Abstract—A spatial filtering method for localizing sources of brain electrical activity from surface recordings is described and analyzed. The spatial filters are implemented as a weighted sum of the data recorded at different sites. The weights are chosen to minimize the filter output power subject ..."
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Cited by 148 (4 self)
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Abstract—A spatial filtering method for localizing sources of brain electrical activity from surface recordings is described and analyzed. The spatial filters are implemented as a weighted sum of the data recorded at different sites. The weights are chosen to minimize the filter output power
Theory and Performance of Narrow Correlator Spacing in a GPS Receiver’, Navigation
- Journal of The Institute of Navigation
, 1992
"... Historically, conventional GPS receivers have used 1.0 chip early-late correlator spacing in the implementation of delay lock loops (DLLs), However, there are distinct advantages to narrowing this spacing, especially in C/A-code tracking applications. These advantages are the reduction of tracking e ..."
Abstract
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Cited by 118 (4 self)
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Historically, conventional GPS receivers have used 1.0 chip early-late correlator spacing in the implementation of delay lock loops (DLLs), However, there are distinct advantages to narrowing this spacing, especially in C/A-code tracking applications. These advantages are the reduction of tracking
Active-site residues in the type IV prepilin peptidase homologue PibD from the archaeon Sulfolobus solfataricus
- J Bacteriol
, 2006
"... Archaeal preflagellin peptidases and bacterial type IV prepilin peptidases belong to a family of aspartic acid proteases that cleave the leader peptides of precursor proteins with type IV prepilin signal sequences. The substrate repertoire of PibD from the crenarchaeon Sulfolobus solfataricus is unu ..."
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Cited by 13 (7 self)
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large cytoplasmic loop is also important for function and is possibly involved in leader peptide recognition. Combining the results of transmembrane segment predictions and cysteine-labeling experiments, we suggest a membrane topology model for PibD with the active-site aspartic acid residues exposed
Results 1 - 10
of
6,734
