Tools
Sorted by:
Try your query at:
 |
 |
 |
 |
 |
 |
Results 1 - 10
of
34
Structural characterization of a rat acinar cell tumor
- J. Cell BioL
, 1982
"... ABSTRACT A transplantable acinar cell tumor of the rat pancreas has been examined by light and electron microscopy. The tumor cells, though highly cytodifferentiated and characterized by the presence of abundant rough-surfaced endoplasmic reticulum, elements of the Golgi complex, and zymogen granule ..."
Abstract
-
Cited by 3 (1 self)
- Add to MetaCart
ABSTRACT A transplantable acinar cell tumor of the rat pancreas has been examined by light and electron microscopy. The tumor cells, though highly cytodifferentiated and characterized by the presence of abundant rough-surfaced endoplasmic reticulum, elements of the Golgi complex, and zymogen
Bim Regulation of Lumen Formation in Cultured Mammary Epithelial Acini Is Targeted by Oncogenes
, 2005
"... Epithelial cells organize into cyst-like structures that contain a spherical monolayer of cells that enclose a central lumen. Using a three-dimensional basement membrane culture model in which mammary epithelial cells form hollow, acinus-like structures, we previously demonstrated that lumen formati ..."
Abstract
- Add to MetaCart
formation is achieved, in part, through apoptosis of centrally localized cells. We demonstrate that the proapoptotic protein Bim may selec-tively trigger apoptosis of the centrally localized acinar cells, leading to temporally controlled lumen formation. Bim is not detectable during early stages of three
BRIEF NOTES 119 The Histochemical Demonstration of Secretory Capillaries in the Pancreas with the Aid
"... Staining of the bile canaliculi in the liver of various mammalian species with histochemical techniques for adenosinetriphosphatase and less regularly 5-nucleotidase at pH 7.2 has been previously reported (i-3). When such techniques were applied to the pancreas, marked enzymatic activity was exhibit ..."
Abstract
- Add to MetaCart
was exhibited by the initial portions of the excretory duct system within the centrally located acinar lumens and the lateral intercellular recesses which extend between neighboring acinar cells. These structures constitute the so called secretory capillaries (Sekretionskapillaren) which can be visualized only
Inhibition of Proliferation by PERK Regulates Mammary Acinar Morphogenesis and Tumor Formation
"... Endoplasmic reticulum (ER) stress signaling can be mediated by the ER kinase PERK, which phosphorylates its substrate eIF2a. This in turn, results in translational repression and the activation of downstream programs that can limit cell growth through cell cycle arrest and/or apoptosis. These respon ..."
Abstract
-
Cited by 7 (0 self)
- Add to MetaCart
and selective upregulation of ATF4 and GADD153. Further, inhibition of endogenous PERK signaling during acinar morphogenesis, using two dominant-negative PERK mutants (PERK-DC or PERK-K618A), does not affect apoptosis but results instead in hyper-proliferative and enlarged lumen-filled acini, devoid of proper
Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells
- Cancer Research
, 2007
"... Maintenance of apico-basal polarity in normal breast epithe-lial acini requires a balance between cell proliferation, cell death, and proper cell-cell and cell-extracellular matrix signaling. Aberrations in any of these processes can disrupt tissue architecture and initiate tumor formation. Here, we ..."
Abstract
-
Cited by 11 (1 self)
- Add to MetaCart
, we show that the small GTPase Rap1 is a crucial element in organizing acinar structure and inducing lumen formation. Rap1 activity in malignant HMT-3522 T4-2 cells is appreciably higher than in S1 cells, their nonmalignant counterparts. Expression of dominant-negative Rap1 resulted in phenotypic
JCB Article Organization of mammary epithelial cells into 3D acinar structures requires glucocorticoid and JNK signaling
"... Mammary epithelial cells cultured on a concentrated laminin-rich extracellular matrix formed 3D acinar structures that matured to polarized monolayers surrounding a lumen. In the absence of glucocorticoids mature acinus formation failed and the expression of an acinus-associated, activator protein 1 ..."
Abstract
- Add to MetaCart
Mammary epithelial cells cultured on a concentrated laminin-rich extracellular matrix formed 3D acinar structures that matured to polarized monolayers surrounding a lumen. In the absence of glucocorticoids mature acinus formation failed and the expression of an acinus-associated, activator protein
UPTAKE AND FATE OF LUMINALLY ADMINISTERED HORSE- RADISH PEROXIDASE IN RESTING AND ISOPROTERENOL- STIMULATED RAT PAROTID ACINAR CELLS
"... The formation and fate of apical endocytic vesicles in resting and isoproterenolstimulated rat parotid acinar cells were studied using luminally administered horseradish peroxidase (HRP) to mark the vesicles. The tracer was taken up from the lumen by endocytosis in small, smooth-surfaced "c&quo ..."
Abstract
- Add to MetaCart
The formation and fate of apical endocytic vesicles in resting and isoproterenolstimulated rat parotid acinar cells were studied using luminally administered horseradish peroxidase (HRP) to mark the vesicles. The tracer was taken up from the lumen by endocytosis in small, smooth-surfaced "
Label Retaining Cells (LRCs) with Myoepithelial Characteristic from the Proximal Acinar Region Define Stem Cells in the Sweat Gland
"... Slow cycling is a common feature shared among several stem cells (SCs) identified in adult tissues including hair follicle and cornea. Recently, existence of unipotent SCs in basal and lumenal layers of sweat gland (SG) has been described and label retaining cells (LRCs) have also been localized in ..."
Abstract
-
Cited by 1 (0 self)
- Add to MetaCart
Slow cycling is a common feature shared among several stem cells (SCs) identified in adult tissues including hair follicle and cornea. Recently, existence of unipotent SCs in basal and lumenal layers of sweat gland (SG) has been described and label retaining cells (LRCs) have also been localized
SYNTHESIS, INTRACELLULAR TRANSPORT, AND DISCHARGE OF SECRETORY PROTEINS IN STIMULATED
"... Our previous observations on the synthesis and transport of secretory proteins in the pancreatic exocrine cell were made on pancreatic slices from starved guinea pigs and accordingly apply to the resting, unstimulated cell. Normally, however, the gland functions in cycles during which zymogen granul ..."
Abstract
- Add to MetaCart
pancreatic slices from starved animals were stimulated in vitro for 3 hr with 0.01 m~t carbamylcholine. During the first hour of treatment the acinar lumen profile is markedly enlarged due to insertion of zymogen granule membranes into the apical plasmalemma accompanying exocytosis of the granule content
unknown title
"... Salivary glands are composed of acinar cells, either serous or mucous, and ductal cells of several varieties. The primary saliva is formed in the lumen of the acinar cells, where the accumulation of ions generates a transepithelial ..."
Abstract
- Add to MetaCart
Salivary glands are composed of acinar cells, either serous or mucous, and ductal cells of several varieties. The primary saliva is formed in the lumen of the acinar cells, where the accumulation of ions generates a transepithelial
Results 1 - 10
of
34
