Results 1 - 10 of 409

Materials for an exploratory theory of the network society.

by Manuel Castells , Anthony Giddens , Alain Touraine , Anthony Smith , Benjamin Barber , Peter Hall , Roger-Pol Droit , Sophie Watson , Frank Webster , Krishan Kumar , David Lyon , Craig Calhoun , Jeffrey Henderson , Ramon Ramos , Jose E Rodrigues-Ibanez , Jose F Tezanos , Mary Kaldor , Stephen Jones , Christopher Freeman - The British Journal of Sociology , 2000
"... ABSTRACT This article aims at proposing some elements for a grounded theor y of the network society. The network society is the social structure characteristic of the Information Age, as tentatively identi ed by empirical, cross-cultural investigation. It permeates most societies in the world, in v ..."
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; social theory; social morphology INTRODUCTION The network society is a speci c form of social structure tentatively identied by empirical research as being characteristic of the Information Age. By social structure I understand the organizational arrangements of humans in relationships of production

1 Drug Design with

by Dr. Paul Janssen
"... In this monograph I would like to tell about the research and the personality of Dr. Paul Janssen, the founder of Janssen Pharmaceutica. Like several of my former colleagues, I have worked for more than forty years with Dr. Paul Janssen or Dr. Paul, as he was always called by his collaborators with ..."
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with much respect and affection. Our first research building was rather small. It comprised a laboratory for chemistry and pharmacology. There wasn’t much more. After five decades the company has expanded to become a large village with more than four thousand people.

Drug Metabolism,

by David C. Evans, Alan P. Watt, Deborah A. Nicoll-griffith, Thomas A. Baillie, Merck Co
"... Running title: Drug bioactivation and covalent binding to proteins 2It is generally accepted that there is neither a well defined nor consistent link between the formation of drug-protein adducts and organ toxicity. Since the potential does exist, however, for these processes to be causally related ..."
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related, the general strategy at Merck Research Laboratories has been to minimize reactive metabolite formation to the extent possible by appropriate structural modification during the lead optimization stage. This requires a flexible approach to defining bioactivation issues in a variety of metabolism

The Power of the Web in Cancer Drug Discovery and Clinical Trial Design: Research without a Laboratory?

by Christine Galustian, Angus G. Dalgleish
"... C o m m e n t a r y ..."
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C o m m e n t a r y

Pneumococcal bacteremia with especial reference to bacteremic pneumococcal pneumonia. Ann Intern Med

by Robert Austrian, Jerome Gold , 1964
"... TWENTY-FIVE YEARS have elapsed since the subject of pneumococcal bacteremia has been reviewed (1, 2). In that period many changes have taken place both in the treatment of this disorder and in the at-titude of the medical profession toward it. T h e introduction of a series of antimicro-bial drugs e ..."
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the validity of these practices and attitudes, established tech-niques for the isolation and identification of pneumococcus were reintroduced as routine procedures in 1952, into the clinical research bacteriologic laboratory of the De-

Targeted inhibitor design: lessons from small molecule drug design, directed evolution, and vaccine research. Chem Eng Process Tech 2013;1:1004

by Sheldon Park , Jasdeep Mann , Naiyi Li
"... Abstract Inhibitors of protein-protein interactions are useful for elucidating novel biology and for manipulating biological processes for therapeutic effects. To this end, both small molecule and protein inhibitors are commonly used. The discovery of novel binders is most often accomplished by scr ..."
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discuss how structural and other molecular data are leveraged to bias high throughput screen and optimize the efficiency of identifying high affinity, functional binders. Examples from small molecule drug design, protein engineering and vaccine research are used to illustrate the point.

Using Computational Thinking for Designing Resistance-Evading Drugs

by Christopher James Langmead , 2008
"... The research objective of this proposal is to apply Computational Thinking to the task of designing drugs against infectious agents (i.e., viruses and bacteria). One of the key challenges in the treatment of viral and bacterial pathogens is the emergence of resistance-conferring mutations. The prese ..."
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The research objective of this proposal is to apply Computational Thinking to the task of designing drugs against infectious agents (i.e., viruses and bacteria). One of the key challenges in the treatment of viral and bacterial pathogens is the emergence of resistance-conferring mutations

Smartgridlab: A laboratory-based smart grid testbed

by Gang Lu Debraj De - In The 1st IEEE International Conference on Smart Grid Communications (IEEE SmartGridComm , 2010
"... Abstract — The evolution of traditional electricity grid into a state-of-the-art Smart Grid will need innovation in a number of dimensions: seamless integration of renewable energy sources, management of intermittent power supplies, realtime demand response, energy pricing strategy etc. The grid con ..."
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flow. In this perspective of unsolved problems, we have designed SmartGridLab, an efficient Smart Grid testbed to help the research community analyze their designs and protocols in lab environment. This will foster the Smart Grid researchers to develop, analyze and compare different designs

Laboratory Validation Study of Drug Evaluation and Classification Program: Ethanol, Cocaine, and Marijuana*

by Stephen J. Heishmanl, Edward G. Singleton, Dennis J. Crouch
"... police agencies to determine if individuals are behaviorally impaired because of drug use, and, if impaired, to determine the class of drug(s) causing the impairment. Although widely used, the validity of the DEC evaluation has not been rigorously tested. The primary goal of this study was to determ ..."
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was to determine the validity of the variables of the DEC evaluation in predicting whether research volunteers had been administered ethanol, cocaine, or marijuana; a secondary goal was to determine the accuracy of trained police officers (Drug Recognition Examiner, DRE) in detecting whether subjects had been

Challenging the trade-off model for the evolution of virulence: is virulence management feasible?

by Dieter Ebert , James J Bull , Dieter Ebert - Trends Microbiol. , 2003
"... Progress in understanding the evolution of infectious diseases has inspired proposals to manage the evolution of pathogen (including parasite) virulence. A common view is that social interventions that lower pathogen transmission will indirectly select lower virulence because of a trade-off between ..."
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infectious diseases, and fears of the evolution of drug resistance in pathogenic microorganisms inspired news headlines and garnered Pulitzer Prizes. In the midst of this was another realization, implying a longer-term use for evolutionary biology: humans themselves might be in a position to manipulate
Results 1 - 10 of 409