of classical approaches with accurate and large-scale sequencing. NGS has the power to identify IG or TR specific for given antigens (in combination with antigen-specific assays) and to define more complex signatures (i.e., TR sets) related to disease and/or treatment from heterogeneous T and B cell

of nucleic acid sequence data and continues to more than double in size every year. New technologies for assaying gene expression patterns, protein structure, protein-protein interactions, etc., will provide even more data. How to handle these data, make sense of them, and render them accessible

I herewith certify that all material in this dissertation which is not my own work has been properly acknowledged.

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An approach based on Extreme Value Theory as a measure to quantify market risk of equity securities and portfolios

Treatment plan optimization for rotating-shield brachytherapy

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(MMOGs) can include millions of concurrent players spread across the world. To keep these highly-interactive virtual environments online, a MMOG operator may need to provision tens of thousands of computing resources from various data centers. Faced with large resource demand variability

Public reporting burden for the collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information,

In presenting this thesis in partial fulfilment of the requirements for a Postgraduate degree