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Benchmarking Least Squares Support Vector Machine Classifiers
 NEURAL PROCESSING LETTERS
, 2001
"... In Support Vector Machines (SVMs), the solution of the classification problem is characterized by a (convex) quadratic programming (QP) problem. In a modified version of SVMs, called Least Squares SVM classifiers (LSSVMs), a least squares cost function is proposed so as to obtain a linear set of eq ..."
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Cited by 446 (46 self)
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In Support Vector Machines (SVMs), the solution of the classification problem is characterized by a (convex) quadratic programming (QP) problem. In a modified version of SVMs, called Least Squares SVM classifiers (LSSVMs), a least squares cost function is proposed so as to obtain a linear set
The Bioperl Toolkit: Perl Modules for the Life Sciences
, 2002
"... Data Type by defining how a given modul wil behave without specifying the mechanism by which it achieves this end. ..."
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Cited by 484 (11 self)
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Data Type by defining how a given modul wil behave without specifying the mechanism by which it achieves this end.
Modeling and simulation of genetic regulatory systems: A literature review
 JOURNAL OF COMPUTATIONAL BIOLOGY
, 2002
"... In order to understand the functioning of organisms on the molecular level, we need to know which genes are expressed, when and where in the organism, and to which extent. The regulation of gene expression is achieved through genetic regulatory systems structured by networks of interactions between ..."
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Cited by 729 (15 self)
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DNA, RNA, proteins, and small molecules. As most genetic regulatory networks of interest involve many components connected through interlocking positive and negative feedback loops, an intuitive understanding of their dynamics is hard to obtain. As a consequence, formal methods and computer tools
Graphical models, exponential families, and variational inference
, 2008
"... The formalism of probabilistic graphical models provides a unifying framework for capturing complex dependencies among random variables, and building largescale multivariate statistical models. Graphical models have become a focus of research in many statistical, computational and mathematical fiel ..."
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Cited by 800 (26 self)
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of probability distributions — are best studied in the general setting. Working with exponential family representations, and exploiting the conjugate duality between the cumulant function and the entropy for exponential families, we develop general variational representations of the problems of computing
ModelBased Clustering, Discriminant Analysis, and Density Estimation
 JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
, 2000
"... Cluster analysis is the automated search for groups of related observations in a data set. Most clustering done in practice is based largely on heuristic but intuitively reasonable procedures and most clustering methods available in commercial software are also of this type. However, there is little ..."
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Cited by 557 (28 self)
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Cluster analysis is the automated search for groups of related observations in a data set. Most clustering done in practice is based largely on heuristic but intuitively reasonable procedures and most clustering methods available in commercial software are also of this type. However
Sparse Bayesian Learning and the Relevance Vector Machine
, 2001
"... This paper introduces a general Bayesian framework for obtaining sparse solutions to regression and classication tasks utilising models linear in the parameters. Although this framework is fully general, we illustrate our approach with a particular specialisation that we denote the `relevance vec ..."
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Cited by 958 (5 self)
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vector machine' (RVM), a model of identical functional form to the popular and stateoftheart `support vector machine' (SVM). We demonstrate that by exploiting a probabilistic Bayesian learning framework, we can derive accurate prediction models which typically utilise dramatically fewer
Limma: linear models for microarray data
 Bioinformatics and Computational Biology Solutions using R and Bioconductor
, 2005
"... This free opensource software implements academic research by the authors and coworkers. If you use it, please support the project by citing the appropriate journal articles listed in Section 2.1.Contents ..."
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Cited by 759 (13 self)
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This free opensource software implements academic research by the authors and coworkers. If you use it, please support the project by citing the appropriate journal articles listed in Section 2.1.Contents
The use of the area under the ROC curve in the evaluation of machine learning algorithms
 Pattern Recognition
, 1997
"... AbstractIn this paper we investigate the use of the area under the receiver operating characteristic (ROC) curve (AUC) as a performance measure for machine learning algorithms. As a case study we evaluate six machine learning algorithms (C4.5, Multiscale Classifier, Perceptron, Multilayer Percept ..."
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Cited by 664 (3 self)
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layer Perceptron, kNearest Neighbours, and a Quadratic Discriminant Function) on six "real world " medical diagnostics data sets. We compare and discuss the use of AUC to the more conventional overall accuracy and find that AUC exhibits a number of desirable properties when compared to overall
A solution to Plato’s problem: The latent semantic analysis theory of acquisition, induction, and representation of knowledge
 PSYCHOLOGICAL REVIEW
, 1997
"... How do people know as much as they do with as little information as they get? The problem takes many forms; learning vocabulary from text is an especially dramatic and convenient case for research. A new general theory of acquired similarity and knowledge representation, latent semantic analysis (LS ..."
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Cited by 1772 (10 self)
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rate to schoolchildren. LSA uses no prior linguistic or perceptual similarity knowledge; it is based solely on a general mathematical learning method that achieves powerful inductive effects by extracting the right number of dimensions (e.g., 300) to represent objects and contexts. Relations to other
Results 1  10
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68,162