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757
CARDIOVASCULAR
"... Full list of author information is available at the end of the articleBackground There is an increasing participation in long-distance running events; there is clear evidence that regular phys-ical activity reduces cardiovascular risk [1-3]. Still, it is unknown if the intensity of physical activity ..."
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Full list of author information is available at the end of the articleBackground There is an increasing participation in long-distance running events; there is clear evidence that regular phys-ical activity reduces cardiovascular risk [1-3]. Still, it is unknown if the intensity of physical
Multimarker approach in cardiovascular risk prediction
, 2009
"... Abstract. Various biomarkers express different pathways and pathophysiologic mechanisms of cardiovascular disease, such as inflammation, oxidative stress, myocardial injury, activation of the neurohormonal pathways, myocardial stress and renal function. Current thinking supports the notion that the ..."
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of the current review is to describe the characteristics of promising biomarkers which have shown an important additive value in the assessment of cardiovascular risk. Also, an extended reference is made regarding studies that address the prognostic value of multimarker models in the settings of primary
RESEARCH Risk functions for prediction of cardiovascular disease in elderly Australians: the Dubbo Study
, 25
"... 1 Patients already manifesting coronary or other arterial disease, or those with diabetes or certain other conditions, were deemed to be at “higher absolute risk ” and would merit intervention with lipid-lowering medication. Others at lesser risk would merit intervention if their absolute risk of ca ..."
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Cited by 5 (0 self)
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of cardiovascular disease (CVD) exceeded 10%– 15 % over the ensuing 5 years — as assessed by a CVD risk calculator2 derived from the Framingham Study. 3 US and European guidelines advocate a generally similar approach, but target risk over 10 years rather than 5 years. 4,5 A recent UK lipid intervention trial
Video Article Assessment and Evaluation of the High Risk Neonate: The NICU Network
"... There has been a long-standing interest in the assessment of the neurobehavioral integrity of the newborn infant. The NICU Network Neurobehavioral Scale (NNNS) was developed as an assessment for the at-risk infant. These are infants who are at increased risk for poor developmental outcome because of ..."
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performance including neurological integrity, behavioral functioning, and signs of stress/abstinence. The NNNS is a noninvasive neonatal assessment tool with demonstrated validity as a predictor, not only of medical outcomes such as cerebral palsy diagnosis, neurological abnormalities, and diseases with risks
The Chinese physicians ’ CardiovAscular Risk Evaluation (CARE) survey: an assessment of
"... Objective To estimate the 10-year risk of cardiovascular disease (CVD)/coronary heart disease (CHD) in physicians using two models (the Chinese and Framingham models). Methods This was a multicentre, cross-sectional survey, which recruited cardiovascular physicians from 386 medical centres in all 31 ..."
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Objective To estimate the 10-year risk of cardiovascular disease (CVD)/coronary heart disease (CHD) in physicians using two models (the Chinese and Framingham models). Methods This was a multicentre, cross-sectional survey, which recruited cardiovascular physicians from 386 medical centres in all
Baseline Cardiovascular Risk Predicts Subsequent Changes in Resting Brain Function
"... Background and Purpose—The Framingham Heart Study group cardiovascular disease risk profile (FCRP) score was used to assess the relationship between baseline cardiovascular risk and subsequent changes in resting state cerebral blood flow (CBF) in cognitively normal older participants from the Baltim ..."
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Background and Purpose—The Framingham Heart Study group cardiovascular disease risk profile (FCRP) score was used to assess the relationship between baseline cardiovascular risk and subsequent changes in resting state cerebral blood flow (CBF) in cognitively normal older participants from
Use and misuse of the receiver operating characteristic curve in risk prediction
- Circulation
, 2007
"... Abstract—The c statistic, or area under the receiver operating characteristic (ROC) curve, achieved popularity in diagnostic testing, in which the test characteristics of sensitivity and specificity are relevant to discriminating diseased versus nondiseased patients. The c statistic, however, may no ..."
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Cited by 56 (0 self)
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not be optimal in assessing models that predict future risk or stratify individuals into risk categories. In this setting, calibration is as important to the accurate assessment of risk. For example, a biomarker with an odds ratio of 3 may have little effect on the c statistic, yet an increased level could shift
Endothelial function as a functional expression of cardiovascular risk factors.
- Biomark Med.
, 2010
"... Abstract Traditional cardiovascular risk (CV) factors based on the Framingham study have been used to estimate the risk of CV events and determine target cholesterol levels for primary prevention. Recently published systematic reviews have, however, demonstrated that the Framingham risk score is li ..."
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Cited by 3 (0 self)
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on endothelial function assessment as a universal tool for prediction of cardiovascular (CV) events in primary and secondary prevention. It also discuses endothelial function as a therapeutic end point to assess efficacy of treatment. Endothelial function is discussed in the context of traditional
General Cardiovascular Risk Profile For Use in Primary Care: The Framingham Heart Study. Circulation
, 2008
"... Background—Separate multivariable risk algorithms are commonly used to assess risk of specific atherosclerotic cardiovascular disease (CVD) events, ie, coronary heart disease, cerebrovascular disease, peripheral vascular disease, and heart failure. The present report presents a single multivariable ..."
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Cited by 34 (1 self)
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risk function that predicts risk of developing all CVD and of its constituents. Methods and Results—We used Cox proportional-hazards regression to evaluate the risk of developing a first CVD event in 8491 Framingham study participants (mean age, 49 years; 4522 women) who attended a routine examination
Bayesian Model Averaging in proportional hazard models: Assessing the risk of a stroke
- Applied Statistics
, 1997
"... Evaluating the risk of stroke is important in reducing the incidence of this devastating disease. Here, we apply Bayesian model averaging to variable selection in Cox proportional hazard models in the context of the Cardiovascular Health Study, a comprehensive investigation into the risk factors for ..."
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Cited by 45 (5 self)
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Evaluating the risk of stroke is important in reducing the incidence of this devastating disease. Here, we apply Bayesian model averaging to variable selection in Cox proportional hazard models in the context of the Cardiovascular Health Study, a comprehensive investigation into the risk factors
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