Bigtable is a distributed storage system for managing structured data that is designed to scale to a very large size: petabytes of data across thousands of commodity servers. Many projects at Google store data in Bigtable, including web indexing, Google Earth, and Google Finance. These applications

We describe Freenet, an adaptive peer-to-peer network application that permits the publication, replication, and retrieval of data while protecting the anonymity of both authors and readers. Freenet operates as a network of identical nodes that collectively pool their storage space to store

The highly successful architecture and protocols of today’s Internet may operate poorly in environments characterized by very long delay paths and frequent network partitions. These problems are exacerbated by end nodes with limited power or memory resources. Often deployed in mobile and extreme

Computer codes for computation and comparison of RNA secondary structures, the Vienna RNA package, are presented, that are based on dynamic programming algorithms and aim at predictions of structures with minimum free energies as well as at computations of the equilibrium partition functions

Emerging high-performance applications require the ability to exploit diverse, geographically distributed resources. These applications use high-speed networks to integrate supercomputers, large databases, archival storage devices, advanced visualization devices, and/or scientific instruments

Increasingly, for many application areas, it is becoming important to include elements of nonlinearity and non-Gaussianity in order to model accurately the underlying dynamics of a physical system. Moreover, it is typically crucial to process data on-line as it arrives, both from the point of view

, we review the "Grid problem," which we define as flexible, secure, coordinated resource sharing among dynamic collections of individuals, institutions, and resources-what we refer to as virtual organizations. In such settings, we encounter unique authentication, authorization, resource

of node identifiers and a predefined geographic hierarchy. Queries for a mobile node's location also use the predefined identifier ordering and spatial hierarchy to find a location server for that node. Experiments using the ns simulator for up to 600 mobile nodes show that the storage and bandwidth

Structured peer-to-peer overlay networks provide a sub-strate for the construction of large-scale, decentralized applications, including distributed storage, group com-munication, and content distribution. These overlays are highly resilient; they can route messages correctly even when a large

partition of the search space and of a grid directory, which are the keys to a dynamic file structure called the grid file. This tile system adapts gracefully to its contents under insertions and deletions, and thus achieves an upper hound of two disk accesses for single record retrieval; it also handles