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Striatal Dopamine Release in Schizophrenia Comorbid with Substance Dependence

by Judy L. Thompson, Ph. D, Nina Urban, Mark Slifstein, Ph. D, Xiaoyan Xu, Ph. D, Lawrence S. Kegeles, Ph. D, Ragy R. Girgis, Yael Beckerman, Jill M
"... Dopamine plays a role in the pathophysiology of schizophrenia and addiction. Imaging studies have indicated that striatal dopamine release is increased in schizophrenia, predominantly in the precommissural caudate (preDCA), and blunted in addiction, mostly in the ventral striatum (VST). Therefore we ..."
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we aimed to measure striatal dopamine release in patients with comorbid schizophrenia and substance dependence. We used [11C]raclopride PET and an amphetamine challenge to measure baseline dopamine D2-receptor availability (BPND) and its percent change post-amphetamine (∆BPND, to index amphetamine

clozapine Differences in craving for cannabis between schizophrenia patients using risperidone, olanzapine or On behalf of: British Association for Psychopharmacology can be found at: Journal of Psychopharmacology Additional services and information for a

by J Psychopharmacol Wiersma , Richard Bruggeman , Wiepke Cahn , Lieuwe De Haan , Lydia Krabbendam , Inez Myin-Germeys , Marise Machielsen , Albertine Scheltema Beduin , Nienke Dekker , René S Kahn , Don H Linszen , Jim Van Os , Durk , Marise Machielsen , Albertine Scheltema Beduin , Nienke Dekker , René S Kahn , Don H Linszen , Jim Van Os , Durk Wiersma , Richard Bruggeman , Wiepke Cahn , Lieuwe De Haan , Lydia Krabbendam , Inez Myin-Germeys
"... Abstract Substance abuse and psychotic disorders have a high rate of comorbidity. Both disorders are associated with changes in the dopaminergic transmission in the mesocorticolimbic pathways of the brain. Since antipsychotic medications interact with the dopamine receptors in these pathways, these ..."
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Abstract Substance abuse and psychotic disorders have a high rate of comorbidity. Both disorders are associated with changes in the dopaminergic transmission in the mesocorticolimbic pathways of the brain. Since antipsychotic medications interact with the dopamine receptors in these pathways

unknown title

by unknown authors
"... Abstract. – BACKGROUND: In this Part II psychiatric disorders coexisting with organic diseases are discussed. “Comorbidity phenomenon ” defines the not univocal interrelation between medical illnesses and psychiatric disorders, each other negatively influencing morbidity and mortality. Most severe p ..."
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psychotropic plants for recreation-al, medicinal, doping or spiritual purpose. After the isolation of active principles or their chemical syn-thesis, higher blood concentrations reached pre-dispose to substance use, abuse and dependence. Abuse substances have specific molecular targets and very different acute
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