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Hypertension With Hemodilution Prevents Multifocal Cerebral Hypoperfusion After Cardiac Arrest in Dogs

by Yuval Leonov, Samuel A. Tisherman, Ken-ichi Oku
"... Background: Improved neurological outcome with postarrest hypertensive hemodilution in an earlier study could be the result of more homogeneous cerebral perfusion and improved O2 delivery. We explored global, regional, and local cerebral blood flow by stable xenon-enhanced computed tomography and gl ..."
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Background: Improved neurological outcome with postarrest hypertensive hemodilution in an earlier study could be the result of more homogeneous cerebral perfusion and improved O2 delivery. We explored global, regional, and local cerebral blood flow by stable xenon-enhanced computed tomography

Inadvertent Occlusion of the Anterior Choroidal Artery Explains Infarct Variability in the Middle Cerebral Artery Thread Occlusion Stroke Model

by Damian D. Mcleod, Daniel J. Beard, Mark W. Parsons, Christopher R. Levi, Mike B. Calford, Neil J. Spratt
"... Intraluminal occlusion of the middle cerebral artery (MCAo) in rodents is perhaps the most widely used model of stroke, however variability of infarct volume and the ramifications of this on sample sizes remains a problem, particularly for preclinical testing of potential therapeutics. Our data and ..."
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and that of others, has shown a dichotomous distribution of infarct volumes for which there had previously been no clear explanation. When studying perfusion computed tomography cerebral blood volume (CBV) maps obtained during intraluminal MCAo in rats, we observed inadvertent occlusion of the anterior choroidal

Double-Blind, Placebo-Controlled Clinical Trial With a Rho-Kinase Inhibitor in Pulmonary Arterial Hypertension -A Pilot Efficacy Trial

by MD Yoshihiro Fukumoto , MD Norikazu Yamada , MD Hiromi Matsubara , PhD; Minori Mizoguchi , PhD; Kazuaki Uchino , MD; Atsushi Yao , PhD; Yasuki Kihara , PhD; Mitsuhiro Kawano , MD Hiroshi Watanabe , PhD; Yutaka Takeda , PhD; Takeshi Adachi , PhD; Shinobu Osanai , PhD; Nobuhiro Tanabe , MD Teruo Inoue , PhD; Akihiro Kubo , Yuri Ota , PhD; Koichiro Fukuda , MD Takeshi Nakano , PhD; Hiroaki Shimokawa
"... Background: We have previously demonstrated that long-term inhibition of Rho-kinase ameliorates pulmonary arterial hypertension (PAH) in animal models. In the present study, we examined the clinical effects of mid-term oral treatment with an extended release formulation of AT-877 (fasudil hydrochlo ..."
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,2,6 Connective tissue disease and liver disease were diagnosed clinically and by blood tests. Congenital heart disease was diagnosed by echocardiography, and chronic thromboembolic pulmonary hypertension was diagnosed by ventilation-perfusion RI scans and computed tomography (CT). 6 Pulmonary function tests

JEAN-LUC GENNISSON

by Universite Paris, Vi Pierre, Et Marie Curie, Espci Paristech, Habilitation A Diriger Des, Dr. Damien, Pr. Michel, Dr. Mickaël, Tanter Examinateur, Jean-luc Gennisson, H. D. R. Université, Paris Vi
"... RECHERCHES Elastographie par ondes de cisaillement ..."
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RECHERCHES Elastographie par ondes de cisaillement
Results 1 - 4 of 4