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Determination and validation of principal gene products
- Bioinformatics
, 2008
"... Motivation: Alternative splicing has the potential to generate a wide range of protein isoforms. For many computational applications and for experimental research it is important to be able to concentrate on the isoform that retains the core biological function. For many genes this is far from clear ..."
Abstract
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Cited by 3 (3 self)
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of non-neutral evolution, the conservation of functional residues, the existence of a known protein structure and the abundance of vertebrate orthologues. The pipeline was able to determine a principal isoform for 83 % of a set of well-annotated genes with multiple variants. 1
Genome analysis Determination and validation of principal gene products
"... Motivation: Alternative splicing has the potential to generate a wide range of protein isoforms. For many computational applications and for experimental research, it is important to be able to concentrate on the isoform that retains the core biological function. For many genes this is far from clea ..."
Abstract
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of non-neutral evolution, the con-servation of functional residues, the existence of a known protein structure and the abundance of vertebrate orthologues. The pipeline was able to determine a principal isoform for 83 % of a set of well-annotated genes with multiple variants. Contact:
Transcript-specific expression profiles derived from sequence-based analysis of standard microarrays
- PLoS ONE
, 2009
"... Background: Alternative mRNA processing mechanisms lead to multiple transcripts (i.e. splice isoforms) of a given gene which may have distinct biological functions. Microarrays like Affymetrix GeneChips measure mRNA expression of genes using sets of nucleotide probes. Until recently probe sets were ..."
Abstract
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Cited by 2 (0 self)
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Background: Alternative mRNA processing mechanisms lead to multiple transcripts (i.e. splice isoforms) of a given gene which may have distinct biological functions. Microarrays like Affymetrix GeneChips measure mRNA expression of genes using sets of nucleotide probes. Until recently probe sets were
