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478
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
- Nucleic Acids Res.
, 1997
"... ABSTRACT The BLAST programs are widely used tools for searching protein and DNA databases for sequence similarities. For protein comparisons, a variety of definitional, algorithmic and statistical refinements described here permits the execution time of the BLAST programs to be decreased substantia ..."
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Cited by 8572 (88 self)
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ABSTRACT The BLAST programs are widely used tools for searching protein and DNA databases for sequence similarities. For protein comparisons, a variety of definitional, algorithmic and statistical refinements described here permits the execution time of the BLAST programs to be decreased
B: A Practical Comparison of De Novo Genome Assembly Software Tools for Next-Generation Sequencing Technologies
- PLoS ONE
"... The advent of next-generation sequencing technologies is accompanied with the development of many whole-genome sequence assembly methods and software, especially for de novo fragment assembly. Due to the poor knowledge about the applicability and performance of these software tools, choosing a befit ..."
Abstract
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Cited by 42 (1 self)
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The advent of next-generation sequencing technologies is accompanied with the development of many whole-genome sequence assembly methods and software, especially for de novo fragment assembly. Due to the poor knowledge about the applicability and performance of these software tools, choosing a
Satisfying Application User Requirements: A Next-Generation Tool Environment for Parallel Systems
, 1995
"... . While productive use of parallel systems for business applications is quickly growing, their usage for scientific applications is far below expectations. The main reason is that programming of parallel systems is still far too complex. Starting from an analysis of the user requirements, it is the ..."
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research objectives, followed by a discussion of three enabling technologies to overcome current-days limitations: formal specification languages, artificial intelligence, and compiler technology. The impact of these technologies on the components proposed for a next-generation programming environment
First steps in programming: A rationale for attention investment models.
- In Proc. HCC, IEEE
, 2002
"... Abstract Research into the cognitive aspects of programming originated in the study of professional programmers (whether experts or students). Even "end-user" programmers What is Programming? Goodell's excellent website devoted to end user programming Programming is in fact seld ..."
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Cited by 110 (16 self)
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be universal and inclusive in its scope, rather than restricted to the experience of "professional" programmers. The next section therefore considers a classification of programming languages that takes account of these user perspectives, rather than conventional definitions. What is a programming
Parallelization of Mapping Algorithms for Next Generation Sequencing Applications
"... With the advent of next-generation high throughput sequencing instruments, large volumes of short sequence data are generated at an unprecedented rate. Processing and analyzing these massive data requires overcoming several challenges. A particular challenge addressed in this abstract is the mapping ..."
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With the advent of next-generation high throughput sequencing instruments, large volumes of short sequence data are generated at an unprecedented rate. Processing and analyzing these massive data requires overcoming several challenges. A particular challenge addressed in this abstract
The past, present, and future of immune repertoire biology—the rise of next-generation repertoire analysis. Front Immunol 4
, 2013
"... T and B cell repertoires are collections of lymphocytes, each characterized by its antigenspecific receptor. We review here classical technologies and analysis strategies developed to assess immunoglobulin (IG) and T cell receptor (TR) repertoire diversity, and describe recent advances in the field ..."
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Cited by 2 (0 self)
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analysis of IG/TR diversity by next-generation sequencing (NGS), offering systematic and comprehensive sequencing of IG/TR transcripts in a short amount of time. NGS provides several angles of analysis such as clonotype frequency, CDR3 diversity, CDR3 sequence analysis, V allele identification with a
Comparison and Evaluation of Multiple Sequence Alignment Tools In Bininformatics
"... Comparison and alignment of a series of protein and DNA sequences were among the first and are now established as the most powerful and frequently used bioinformatics methods. A variety of computational algorithms and programs have been created for this purpose. Decision about which tools to use is ..."
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Comparison and alignment of a series of protein and DNA sequences were among the first and are now established as the most powerful and frequently used bioinformatics methods. A variety of computational algorithms and programs have been created for this purpose. Decision about which tools to use
Validation of Next Generation Sequencing Technologies in Comparison to Current Diagnostic Gold Standards for BRAF, EGFR and KRAS Mutational Analysis
"... Next Generation Sequencing (NGS) has the potential of becoming an important tool in clinical diagnosis and therapeutic decision-making in oncology owing to its enhanced sensitivity in DNA mutation detection, fast-turnaround of samples in comparison to current gold standard methods and the potential ..."
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Next Generation Sequencing (NGS) has the potential of becoming an important tool in clinical diagnosis and therapeutic decision-making in oncology owing to its enhanced sensitivity in DNA mutation detection, fast-turnaround of samples in comparison to current gold standard methods and the potential
Materials for an exploratory theory of the network society.
- The British Journal of Sociology
, 2000
"... ABSTRACT This article aims at proposing some elements for a grounded theor y of the network society. The network society is the social structure characteristic of the Information Age, as tentatively identi ed by empirical, cross-cultural investigation. It permeates most societies in the world, in v ..."
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Cited by 122 (0 self)
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domain of our eco-social system is thereby transformed. We live in a new economy, characterized by three fundamental features. First, it is informational , that is, the capacity of generating knowledge and processing/managing information determine the productivity and competitiveness of all kinds
A Study of User-Friendly Hash Comparison Schemes
"... Abstract—Several security protocols require a human to compare two hash values to ensure successful completion. When the hash values are represented as long sequences of numbers, humans may make a mistake or require significant time and patience to accurately compare the hash values. To improve usab ..."
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Abstract—Several security protocols require a human to compare two hash values to ensure successful completion. When the hash values are represented as long sequences of numbers, humans may make a mistake or require significant time and patience to accurately compare the hash values. To improve
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