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159
Sigma-1 Receptor Agonists Directly Inhibit NaV1.2/1.4 Channels
, 2012
"... (+)-SKF 10047 (N-allyl-normetazocine) is a prototypic and specific sigma-1 receptor agonist that has been used extensively to study the function of sigma-1 receptors. (+)-SKF 10047 inhibits K+, Na+ and Ca2+ channels via sigma-1 receptor activation. We found that (+)-SKF 10047 inhibited Na 1.2 and Na ..."
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(+)-SKF 10047 (N-allyl-normetazocine) is a prototypic and specific sigma-1 receptor agonist that has been used extensively to study the function of sigma-1 receptors. (+)-SKF 10047 inhibits K+, Na+ and Ca2+ channels via sigma-1 receptor activation. We found that (+)-SKF 10047 inhibited Na 1
How Many Queries are Needed to Learn?
, 1996
"... We investigate the query complexity of exact learning in the membership and (proper) equivalence query model. We give a complete characterization of concept classes that are learnable with a polynomial number of polynomial sized queries in this model. We give applications of this characterization, i ..."
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Cited by 70 (9 self)
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: If any "honest" class is exactly and properly learnable with polynomial query complexity, but not learnable in polynomial time, then P<F NaN> 6= NP. In particular, we show that an honest class is exactly polynomial-query learnable if and only if it is learnable using an oracle for \Sigma
Licence Creative Commom CC Association between unhealthy behavior and sleep quality and duration in adolescents Associação entre comportamento não saudável e qualidade e duração do sono em adolescentes
"... Abstract -Inadequate sleep has been associated with unhealthy behavior in adolescence. This study aimed to estimate the prevalence of negative sleep indicators (perceived poorquality sleep and insufficient sleep duration) among students and to identify unhealthy behaviors associated with this outco ..."
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with this outcome. This study is part of a school-based, cross-sectional survey conducted in 2011 in adolescents from Santa Catarina State, Brazil. High school students aged 15 to 19 years (n = 6,529) and enrolled in state public schools participated in the study. The students responded to a questionnaire
AS NOVAS EXIGÊNCIAS DA COMUNICAÇÃO CIENTÍFICA NA ERA DO CONHECIMENTO
"... Tanto o produto quanto o processo da atividade científica são dependentes de comunicação eficaz. Muitos cientistas e analistas em ciência e tecnologia já se deram conta deste fato, afirmando que não existe ciência sem comunicação(1-6). Dentre variadas possibilidades de mecanismos para difusão e comp ..."
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publicação, representa a consagração desse valor o qual, por sua vez, terá uma variação em função do prestígio do periódico em que foi publicado. Neste contexto, é fácil deduzir que o prestígio do periódico está intimamente relacionado à qualidade da arbitragem e dos manuscritos submetidos. Estes constituem
For Publisher's use RARE \Xi 0 DECAYS: NEW RESULTS FROM NA48
"... 1 Introduction Weak radiative \Xi 0 decays can be used to study the mechanisms of SU(3) symmetry breaking. However, past investigations have not led to a conclusive picture. On the theoretical side, a variety of models exist with predictions varying by an order of magnitude.1;2;3;4;5 Experimentally, ..."
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, the situation is unclear, too: Branching ratio measurements agree for \Xi 0! \Sigma 0fl,6;7 but do not for \Xi 0! \Lambda fl.6;8 The interest in \Xi 0! \Sigma +e\Gamma _*e, the analogue to neutron beta decay, stems from its potential to study flavor symmetry violation.
REBEN_68-6_MIOLO_ING.indd
"... ABSTRACT Objective: to identify the attributes of the "family insuffi ciency" concept of the aged in the literature. Method: critical literature analysis. Results: family insuffi ciency is characterized as a complex process of psychosocial interaction, founded mainly on low social support ..."
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da saúde psicológica e funcional, a menor qualidade de vida e o envelhecimento mal sucedido. Elaborou-se uma proposta teórica inédita para o conceito de insufi ciência familiar na pessoa idosa com os atributos, antecedentes e consequentes identifi cados. Conclusão: os achados deste estudo constituem
Single-molecule high-resolution imaging with photobleaching.
- Proc. Natl. Acad. Sci. USA
, 2004
"... Conventional light microscopy is limited in its resolving power by the Rayleigh limit to length scales on the order of 200 nm. On the other hand, spectroscopic techniques such as fluorescence resonance energy transfer cannot be used to measure distances >10 nm, leaving a ''gap'&ap ..."
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Cited by 35 (0 self)
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silanized by using a procedure derived from ref. 14. Coverslips were cleaned as above and then incubated in 6 mM 3-aminopropyltriethoxysilane (APTES, Sigma-Aldrich), pH Ϸ3, at 60°C for 17.5 h. They were then rinsed with water and stored in distilled ethanol. Doubly labeled DNA samples were diluted to ϳ100 p
1Supporting Information to: Inhibitory Effect of the Norlignan 2-(2-Hydroxy-4,6- dimethoxyphenyl)-5-[(E)-propenyl]benzofuran from Krameria tomentosa on Acetylcholine-Induced Relaxation of the Rat Aorta
"... The drugs used in our experiments acetylcholine, carbachol, cremophor, phenylephrine, SIN-1 (3-morpholinosydnonimine) and SOD (superoxide dismutase) were purchased from Sigma (USA). The isolation and identification of DMPP (colorless crystals, m.p. 121 123 °C, purity ~ 95 % by HPLC) is described ..."
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) is described in detail elsewhere [1]. Before the realization of the experiments, the tissues were maintained in gassed (95 % O2 + 5 % CO2) solution at 37 °C, under a tension of 1 g. The rat aorta and guinea-pig ileum and trachea were set up in Krebs-Henseleit (mM): NaCl 110.8, KCl 5.9, NaHCO3 25.0, MgSO4 1
Asymmetric centrosome inheritance maintains neural progenitors in the neocortex. Nature 461: 947–955
, 2009
"... Abstract Asymmetric divisions of radial glial progenitors produce self-renewing radial glia and differentiating cells simultaneously in the ventricular zone (VZ) of the developing neocortex. While differentiating cells leave the VZ to constitute the future neocortex, renewing radial glial progenito ..."
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Cited by 31 (1 self)
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Morph (Molecular Devices) and Photoshop (Adobe Systems). Methods Plasmids and in utero electroporation and photo-conversion shRNA-a (5′-GCAGAAGGCCAGCTGAGGT-3′), -b (GGCCGAGATCCGGCACTTG), -c (GCTTCAATTCAGACAATGG). All sense and anti-sense oligos were purchased from Sigma. Annealed oligos were cloned into the Hpa
annotate-methods Automatic deconvolution/annotation of LC/ESI-MS data Description Usage
, 2012
"... Wrapper skript for automatic annotation of isotope peaks, adducts and fragments for a (grouped) xcmsSet xs. The function returns an xsAnnotate object. annotate(object, sample=NA, nSlaves=1, sigma=6, perfwhm=0.6, cor_eic_th=0.75, graphMethod="hcs", pval=0.05, calcCiS=TRUE, ..."
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Wrapper skript for automatic annotation of isotope peaks, adducts and fragments for a (grouped) xcmsSet xs. The function returns an xsAnnotate object. annotate(object, sample=NA, nSlaves=1, sigma=6, perfwhm=0.6, cor_eic_th=0.75, graphMethod="hcs", pval=0.05, calcCiS=TRUE,
Results 1 - 10
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159
