Searching for authors named "Olivier Lichtarge" – sorted by Relevance.

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8 documents found, showing 1 through 8.

Character and evolution of protein-protein interfaces
by Olivier Lichtarge — 2005 — Biol
…Protein–protein interactions create the macromolecular assemblies and sequential signaling pathways essential for cell function. Their number far exceeds the number of proteins themselves and their experimental characterization, while improving, remains relatively slow. For these reasons, novel comp…
Cited by 3 (0 self) – Add To MetaCart

BIOINFORMATICS APPLICATIONS NOTE Structural bioinformatics
by Daniel H. Morgan, David M. Kristensen, David Mittelman, Olivier Lichtarge — 2006
…Vol. 22 no. 16 2006, pages 2049–2050 doi:10.1093/bioinformatics/btl285 ET viewer: an application for predicting and visualizing functional sites in protein structures…
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An evolutionary trace method defines binding surfaces common to protein families
by Olivier Lichtarge, Henry R. Bourne, Fred E. Cohen — 1996 — J. Mol. Biol
…1Departments of Cellular and X-ray or NMR structures of proteins are often derived without their Molecular Pharmacology and ligands, and even when the structure of a full complex is available, the area Medicine and of contact that is functionally and energetically significant may be a 2Department of…
Cited by 86 (7 self) – Add To MetaCart

Identification of Functional Surfaces of the Zinc
by Binding Domains Of, Olivier Lichtarge, Keith R. Yamamoto, Fred E. Cohen — 1997 — J. Mol. Biol
…Introduction Intracellular receptors (IRs) constitute the largest superfamily of eukaryotic transcription factors. In response to small extracellular ligands such as steroid, thyroid and retinoid hormones, they bind to specic genomic response elements (REs) and exert transcriptional regulation over…
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A Statistical Model to Correct Systematic Bias Introduced by Algorithmic Thresholds in Protein Structural Comparison Algorithms
by Viacheslav Y. Fofanov, Brian Y. Chen, Drew H. Bryant, Mark Moll, Olivier Lichtarge, Lydia Kavraki, Marek Kimmel
…§ equal contribution, ∗ work performed while author was with Rice University The identification of protein function is crucial to understanding cellular processes and selecting novel proteins as drug targets. However, experimental methods for determining protein function can be expensive and time-c…
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Algorithms for structural comparison and statistical analysis of 3D protein motifs
by B. Y. Chen, V. Y. Fofanov, D. M. Kristensen, M. Kimmel, O. Lichtarge, L. E. Kavraki, Brian Y. Chen, Viacheslav Y. Fofanov, David M. Kristensen, Marek Kimmel, Olivier Lichtarge, Lydia E. Kavraki — 2005 — Proc. Pac. Symp. Biocomp. (PSB
…The comparison of structural subsites in proteins is increasingly relevant to the prediction of their biological function. To address this problem, we present the Match Augmentation algorithm (MA). Given a structural motif of interest, such as a functional site, MA searches a target protein structur…
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Evolutionary trace-based peptides identify a novel asymmetric interaction that mediates oligomerization in nuclear receptors
by Peili Gu, Daniel H. Morgan, Minawar Sattar, Xueping Xu, Ryan Wagner, Michele Raviscioni, Olivier Lichtarge, Austin J. Cooney — 2005 — J. Biol. Chem
…Germ cell nuclear factor (GCNF) is an orphan nuclear receptor that plays important roles in development and reproduction, by repressing the expression of essential genes such as Oct4, GDF9, and BMP15, through binding to DR0 elements. Surprisingly, whereas recombinant GCNF binds to DR0 sequences as a…
Cited by 1 (1 self) – Add To MetaCart

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