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ABSTRACT Dengue is a mosquito-borne infection found in tropical and subtropical regions around the world. In recent years, transmission has increased predominantly in urban and semi-urban areas and which has been of major concern to governments and the World Health Organization (WHO). Dengue fever regardless of its serotypes has been the most prevalent arthropod-borne viral diseases among the world population. The development of a dengue vaccine is complicated by the antibodydependent enhancement effect. Thus, the development of a plant-based antiviral preparation promises a more potential alternative in combating dengue disease. The demand for plant-based medicines is growing as they are generally considered to be safer, non-toxic and less harmful than synthetic drugs. Current studies show that natural products represent a rich potential source of new anti-dengue compounds. Further laboratory investigations are needed established the potential of identified species in contributing to dengue control. This is short review to notice some phytochemical structure from plant sources for dengue fever.

ABSTRACT In this study, we were determining the anti-ulcer effect of Haldina cordifolia in NSAID induced rats. The methanolic extract was given orally 100mg/kg and 50 mg/kg body weight at 8 hrs interval. Diclofenac sodium was used as the inducing agent for the ulcer. The result was satisfactory as there is a marked improvement in the ulcerated part. The extract was able to decrease the acid secretion in stomach and increase the mucosal damage.

Emblica officinalis is a natural, efficacious, an antioxidant with the richest natural source of Vitamin C. Emblica officinalis berries have the highest amount of naturally occurring vitamin C of any ripe fruit in the world used as a traditional food. Numerous studies conducted on Emblica officinalis fruit suggest that it has anti-viral properties and also functions as an anti-bacterial and anti-fungal agent. The gelatinous plum-sized Amla fruit contains naturally occurring vitamin, heat stable vitamin C. A clinical study on patients with pulmonary tuberculosis showed that the vitamin C contained in Emblica officinalis was better assimilated than synthetic vitamin C. Further research of contemporary and traditional medical literature indicates that Emblica officinalis either in combination with other herbs or alone has been useful in the amelioration of colds, warts, skin afflictions, influenza, anemia, diabetes, lung conditions, elevated cholesterol and as an immune restorative in cancer conditions. It is one of the best natural anti-ageing remedies Emblica officinalis is used in treatment of Acne and other skin problems. Emblica officinalis is amazingly effective natural anti-ageing product. Emblica officinalis is very effective in treatment of Acidity and Peptic ulcers. Emblica officinalis is rich in Vitamin C, Calcium, Iron, essential amino acids and many other vitamins

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ABSTRACT The main objective of this study is to investigate the safety and efficacy of herbal ointment formulated with methanolic extract of Mikania cordata as Treatment for acute superficial injury. Ointment was prepared by fusion method using emulsifying ointment as base. The formulation was then tested for its physicochemical properties like loss of drying, pH, spreadability, extrudability, together with diffusion study and gave a satisfactory result. The prepared ointment was also stable at 4 0 C, 25 0 C and 37 0 C. Further, the formulation was evaluated for its antibacterial activity against Staphylococcus aureus, Pseudomonas sp., Bacillus sp., by agar diffusion method by using Mupirocin (6%w/w) as a standard. The formulation showed significant (p<0.01) activity against Staphylococcus areus and Bacillus sp compared to Mupirocin ointment which showed a significant (p<0.01) activity against Pseudomonas sp and E. coli. Antioxidant activity of the extract through reducing power assay showed that the scavenging activity of the formulation increased with increase in concentration due to the presence of flavonoids and tannins. The dermatological effect of the herbal ointment was carried out by applying a considerable amount of the ointment on the skin surface area of ten healthy individuals in phase I clinical trial and showed a satisfactory result with no allergic or irritation reaction. Evaluation of the healing potency of the extract was carried out on twenty individuals with acute superficial injuries in phase II clinical trial and showed a significant (p<0.01) wound treatment index of 5.43±0.37 and a percentage reduction index of 28.26±4.14. The standard treatment drug mupirocin also showed a significant difference (p<0.01) with a treatment index of 4.47±0.26cm and a wound percentage reduction index of 21.68±3.76. Paired sample correlations showed no significant difference (p>0.01) between those treated with M. cordata and those treated with mupirocin. Overall result of this study reveals that the herbal ointment of Mikania cordata is safe and as pharmacologically competent as Mupirocin and can be used as treatment for superficial injuries.