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Apoptosis: a Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics

by J. F. R. Kerr, A. H. Wyllie, A. R. Curriet - Br. J. Cancer , 1972
"... Summary.-The term apoptosis is proposed for a hitherto little recognized mechanism of controlled cell deletion, which appears to play a complementary but opposite role to mitosis in the regulation of animal cell populations. Its morphological features suggest that it is an active, inherently program ..."
Abstract - Cited by 641 (6 self) - Add to MetaCart
Summary.-The term apoptosis is proposed for a hitherto little recognized mechanism of controlled cell deletion, which appears to play a complementary but opposite role to mitosis in the regulation of animal cell populations. Its morphological features suggest that it is an active, inherently

CELL POPULATION KINETICS OF AN OSTEOGENIC TISSUE-

by Owen D. Phil
"... Cell proliferation on the actively growing periostcal surface of the femur of rabbits aged 2 weeks has been investigated using autoradiographic techniques. Injections of tritiated glycine and tritiated thymidine were given simultaneously and the animals sacrificed at intervals from 1 hour to 5 days ..."
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injection. The cell kinetics of the fibroblast-pre-osteoblast-osteoblast-osteocyte system has been studied. The fibroblasts are relatively unimportant from the point of view of increase in the cell population. The main site of cell proliferation is the layer of pre-osteoblasts on the periosteal surface

QUASTLER H: Cell population kinetics in the colon of the mouse

by Lipkin, Henry Quastler - 1 Clin Invest , 1966
"... In recent years interest in the cell population kinetics of gastrointestinal mucosa has been stimu-lated by several factors. One is the realization that the turnover rates of mucosal cell populations are among the most rapid in the body (1). Another is the possibility that abnormal histologic appear ..."
Abstract - Cited by 8 (1 self) - Add to MetaCart
In recent years interest in the cell population kinetics of gastrointestinal mucosa has been stimu-lated by several factors. One is the realization that the turnover rates of mucosal cell populations are among the most rapid in the body (1). Another is the possibility that abnormal histologic

CELL POPULATION KINETICS OF EXCISED ROOTS OF PISUM SATIVUM

by Jack Van't Hob
"... The cell population kinetics of excised, cultured pea roots was studied with the use of tritiated thymidine and colchicine to determine (1) the influence of excision, (2) the influence of sucrose concentration, (3) the average mitotic cycle duration, and (4) the duration of mitosis and the G1, S, an ..."
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The cell population kinetics of excised, cultured pea roots was studied with the use of tritiated thymidine and colchicine to determine (1) the influence of excision, (2) the influence of sucrose concentration, (3) the average mitotic cycle duration, and (4) the duration of mitosis and the G1, S

Population kinetics of rat peripheral B cells

by David Gray - J Exp Med , 1988
"... Studies of B lymphopoiesis in the bone marrow of adult mice (1, 2) and rats (3) suggest that the rate of production is sufficient to totally replace the peripheral B cell pool within 4-5 d. This assumes first that there is no significant loss of cells between the stages of A. chain gene rearrangemen ..."
Abstract - Cited by 2 (0 self) - Add to MetaCart
emerge into peripheral lymphoid organs (4, 5). More convincingly, the rate of repopulation of the B cell compartment after depletion by long-term treatment with anti-,u and anti-S antibodies is very rapid and correlates well with this estimate of 4-5 d (6). Is the turnover of B cell populations in normal

CELL POPULATION KINETICS OF AN OSTEOGENIC TISSUE. II

by Maureen Owen, D. Phil, Sheila Macpherson, D. Phil
"... A study of the cell kinetics on the actively growing periostcal surface of the femur of rabbits aged 2 wecks has been continued. A single injection of tritiated thymidine was given and the rabbits killed from l hour to 4 days after injection. The grain count spectra of thc differcnt cell types, pre- ..."
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A study of the cell kinetics on the actively growing periostcal surface of the femur of rabbits aged 2 wecks has been continued. A single injection of tritiated thymidine was given and the rabbits killed from l hour to 4 days after injection. The grain count spectra of thc differcnt cell types, pre

Performance of gentamicin population kinetic parameters in Portuguese neonates

by Marı´lia J Rocha , A E Anabela , M Almeida , A E Amı´lcar , C Falca˜o , A E Margarida , M Caramona
"... Abstract Aim: To evaluate the performance of eight different sets of gentamicin populational pharmacokinetic parameters, regarding potential implementation in clinical pharmacokinetic software as prior information. Methods: The study involved 49 patients of 31.3±4.1 weeks of gestational age (GA), r ..."
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Abstract Aim: To evaluate the performance of eight different sets of gentamicin populational pharmacokinetic parameters, regarding potential implementation in clinical pharmacokinetic software as prior information. Methods: The study involved 49 patients of 31.3±4.1 weeks of gestational age (GA

FOR THE NUMERICAL SIMULATIONS OF IN VITRO HUMAN TUMOR CELL POPULATION KINETICS

by Z. Jackiewicz, B. Zubik-kowal, B. Basse
"... Abstract. Pseudo-spectral approximations are constructed for the model equa-tions which describe the population kinetics of human tumor cells in vitro and their responses to radiotherapy or chemotherapy. These approximations are more efficient than finite-difference approximations. The spectral accu ..."
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Abstract. Pseudo-spectral approximations are constructed for the model equa-tions which describe the population kinetics of human tumor cells in vitro and their responses to radiotherapy or chemotherapy. These approximations are more efficient than finite-difference approximations. The spectral

From kuramoto to crawford: exploring the onset of synchronization in populations of coupled oscillators

by Steven H. Strogatz - Phys. D , 2000
"... The Kuramoto model describes a large population of coupled limit-cycle oscillators whose natural frequencies are drawn from some prescribed distribution. If the coupling strength exceeds a certain threshold, the system exhibits a phase transition: some of the oscillators spontaneously synchronize, w ..."
Abstract - Cited by 302 (4 self) - Add to MetaCart
The Kuramoto model describes a large population of coupled limit-cycle oscillators whose natural frequencies are drawn from some prescribed distribution. If the coupling strength exceeds a certain threshold, the system exhibits a phase transition: some of the oscillators spontaneously synchronize

The Growth and Cell Population Kinetics of Spontaneous Tumours in Domestic Animals

by L. N. Owen, G. G. Steel - Br. J. Cancer , 1969
"... INVESTIGATIONS into the relationship between cell proliferation and overall tumour growth rate in human cancer have to contend with the major limitation that only rarely can both cell kinetic data and information on volume growth rate be obtained in one and the same patient. When a case is operable ..."
Abstract - Cited by 2 (1 self) - Add to MetaCart
INVESTIGATIONS into the relationship between cell proliferation and overall tumour growth rate in human cancer have to contend with the major limitation that only rarely can both cell kinetic data and information on volume growth rate be obtained in one and the same patient. When a case is operable
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